AI Article Synopsis
- - The rising global issue of cadmium (Cd) contamination is linked to negative pregnancy effects, including miscarriages, highlighting a need for more thorough research on this topic.
- - This study reviews existing animal models and clinical trials related to Cd-induced miscarriage and explores mechanisms like oxidative stress, inflammation, and placental dysfunction.
- - Potential pharmacological interventions, including melatonin, vitamin C, and vitamin E, are discussed for their roles in reducing the harmful outcomes of Cd exposure during pregnancy.
Article Abstract
The prevalence of cadmium (Cd) contamination has emerged as a significant global concern. Exposure to Cd during pregnancy is associated with adverse pregnancy outcomes, including miscarriage. However, there is currently a lack of comprehensive summaries on Cd-induced miscarriage. Therefore, it is imperative to further strengthen research into in vivo studies, clinical status, pathological mechanisms, and pharmacological interventions for Cd-induced miscarriage. This study systematically presents the current knowledge on animal models and clinical trials investigating Cd exposure-induced miscarriage. The underlying mechanisms involving oxidative stress, inflammation, endocrine disruption, and placental dysfunction caused by Cd-induced miscarriage are also extensively discussed. Additionally, potential drug interventions such as melatonin, vitamin C, and vitamin E are highlighted for their pharmacological role in mitigating adverse pregnancy outcomes induced by Cd.
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| http://dx.doi.org/10.1016/j.ecoenv.2024.116118 | DOI Listing |
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