Liposomes for the treatment of prostate cancer therapy: A review.

Cancer Treat Res Commun

MIT College of Pharmacy, MIT Campus, Moradabad (Affiliated to Dr. A.P.J. Abdul Kalam Technical University), Ram Ganga vihar, Phase-II, UP, 244001, India.

Published: May 2024

AI Article Synopsis

  • Prostate cancer is a significant health issue for men worldwide, with diagnoses made through examinations and tests, and its progression linked to genetic mutations.
  • Treatment options vary depending on the stage of cancer, with localized cases being treated through surgery or radiation, while advanced stages utilize hormone therapy and chemotherapy.
  • The review explores liposome-based drug delivery systems as a promising alternative to traditional treatments, highlighting their advantages in targeting cancer cells and their ongoing clinical trials for various types of cancer, including prostate cancer.

Article Abstract

One of the cancers that affect men, prostate cancer considerably raises mortality rates for males around the world. Patients with prostate cancer can have a localized or advanced form of the illness. Digital rectal examinations, prostate-specific antigen analyses, and prostate biopsies are all used to identify prostate cancer. The onset, development, and spread of cancer are all correlated with mutations in specific genes. Radical prostatectomy, ablative radiation, and active surveillance are all forms of treatment for localized prostate cancer. Androgen deprivation therapy (ADT), radiation, and chemotherapy are given to men who have metastatic prostate cancer or have experienced a relapse. When compared to traditional cancer chemotherapeutic methods, the liposome-based drug delivery technology offers less toxic, biodegradable, and biocompatible nanomedicine. Liposomes offer great advantages for use in nanomedicines by improving the sensitivity, specificity, and persistence of these anti-malignant cell agents in the body. Liposomal formulations are undergoing clinical trials of variety of cancers including prostate cancer. The present narrative review describes the composition and types of liposomes, its advantages, disadvantages, and the methods of preparation, research studies, clinical applications, drug repurposing and administration.

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Source
http://dx.doi.org/10.1016/j.ctarc.2024.100792DOI Listing

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