AI Article Synopsis
- Researchers sequenced the genomes of two Trichophyton indotineae isolates from patients, highlighting potential connections to overseas water exposure and varying ages.* -
- There were no significant mutations in key genes related to drug susceptibility, indicating the isolates were susceptible to antifungal treatments.* -
- The analysis revealed a genetic distance of 92 SNPs between the two isolates, suggesting a close relationship with other South Asian strains, indicating that T. indotineae might be more common than previously recognized.*
Article Abstract
Complete genome sequences from two Trichophyton indotineae isolates were obtained from a 23-year-old male presenting with tinea cruris after an overseas recreational water exposure and from a 53-year-old female patient with unknown travel history. Analysis of the squalene epoxidase gene and the cyp51 gene family showed an absence of mutations, correlating with phenotypic drug susceptibility. The Single Nucleotide Polymorphisms (SNPs) distance between both isolates was 92. Within the T. indotineae cluster, SNPs ranged from 7 to 182, suggesting a high genetic relatedness with other South Asian isolates. This study suggests that the prevalence of T. indotineae is under-reported and more widespread than previously thought.
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| http://dx.doi.org/10.1093/mmy/myae012 | DOI Listing |
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