AI Article Synopsis
- Progressive multifocal leukoencephalopathy (PML) is a rare neurological disorder caused by the reactivation of the JC polyomavirus (JCPyV).
- The study focused on analyzing gene expression and viral changes in PML-affected brain tissue, highlighting how the virus infects specific brain cells like astrocytes and oligodendrocytes.
- Findings indicated significant changes in human genes linked to neuroinflammation and neurodegenerative diseases, suggesting a strong immune response in the brains of PML patients.
Article Abstract
Progressive multifocal leukoencephalopathy (PML) is a rare neurological condition associated with reactivation of dormant JC polyomavirus (JCPyV). In this study, we characterized gene expression and JCPyV rearrangements in PML brain tissue. Infection of white matter astrocytes and oligodendrocytes as well as occasional brain cortex neurons was shown. PML brain harbored exclusively rearranged JCPyV variants. Viral transcripts covered the whole genome on both strands. Strong differential expression of human genes associated with neuroinflammation, blood-brain barrier permeability, and neurodegenerative diseases was shown. Pathway analysis revealed wide immune activation in PML brain. The study provides novel insights into the pathogenesis of PML.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420775 | PMC |
| http://dx.doi.org/10.1093/infdis/jiae066 | DOI Listing |
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