AI Article Synopsis
- - The study highlights the emergence of transferable linezolid resistance genes in Staphylococcus aureus from pig carcasses, which not only leads to linezolid resistance but also lowers susceptibility to florfenicol, a common veterinary antibiotic
- - Out of over 2500 strains analyzed, 15 showed high levels of linezolid resistance, with significant genetic diversity and one novel strain type identified (ST8004) that had not been reported before
- - These resistant strains carry multiple antibiotic resistance genes and enterotoxin gene clusters, raising concerns about the potential for these genes to spread between bacteria, necessitating ongoing monitoring of these resistant strains in animals and food products
Article Abstract
The emergence of transferable linezolid resistance genes poses significant challenges to public health, as it does not only confer linezolid resistance but also reduces susceptibility to florfenicol, which is widely used in the veterinary field. This study evaluated the genetic characteristics of linezolid-resistant Staphylococcus aureus strains isolated from pig carcasses and further clarified potential resistance and virulence mechanisms in a newly identified sequence type. Of more than 2500 strains isolated in a prior study, 15 isolated from pig carcasses exhibited linezolid resistance (minimum inhibitory concentration ≥ 8 mg/L). The strains were characterized in detail by genomic analysis. Linezolid-resistant S. aureus strains exhibited a high degree of genetic lineage diversity, with one strain (LNZ_R_SAU_64) belonging to ST8004, which has not been reported previously. The 15 strains carried a total of 21 antibiotic resistance genes, and five carried mecA associated with methicillin resistance. All strains harbored cfr and fexA, which mediate resistance to linezolid, phenicol, and other antibiotics. Moreover, the strains carried enterotoxin gene clusters, including the hemolysin, leukotoxin, and protease genes, which are associated with humans or livestock. Some genes were predicted to be carried in plasmids or flanked by ISSau9 and the transposon Tn554, thus being transmittable between staphylococci. Strains carrying the plasmid replicon repUS5 displayed high sequence similarity (99%) to the previously reported strain pSA737 in human clinical samples in the United States. The results illustrate the need for continuous monitoring of the prevalence and transmission of linezolid-resistant S. aureus isolated from animals and their products.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10874063 | PMC |
| http://dx.doi.org/10.1186/s13567-024-01278-x | DOI Listing |
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