AI Article Synopsis
- - The increasing incidence of multiple primary lung cancer (MPLC) has led to a new category called "super MPLC," characterized by numerous lesions at diagnosis.
- - Researchers conducted whole exome sequencing and immunohistochemistry analysis on tumor samples from patients with super MPLC, revealing significant genomic alterations such as mutations in EGFR, RBM10, and TP53, along with TERT amplification.
- - The study highlights differences in the immune microenvironment of super MPLC compared to traditional lung cancers, suggesting unique clinical features and potential therapeutic approaches based on its distinct genomic characteristics.
Article Abstract
Background: In recent years, a growing number of patients with multiple primary lung cancer (MPLC) are being diagnosed, and a subset of these patients is found to have a large number of lesions at the time of diagnosis, which are referred to as 'super MPLC'.
Methods: Here, we perform whole exome sequencing (WES) and immunohistochemistry (IHC) analysis of PD-L1 and CD8 on 212 tumor samples from 42 patients with super MPLC.
Findings: We report the genomic alteration landscape of super MPLC. EGFR, RBM10 and TP53 mutation and TERT amplification are important molecular events in the evolution of super MPLC. We propose the conception of early intrapulmonary metastasis, which exhibits different clinical features from conventional metastasis. The IHC analyses of PD-L1 and CD8 reveal a less inflamed microenvironment of super MPLC than that of traditional non-small cell lung cancer (NSCLC). We identify the potentially susceptible germline mutations for super MPLC.
Interpretation: Our study depicts the genomic characteristics and immune landscape, providing insights into the pathogenesis and possible therapeutic guidance of super MPLC.
Funding: A full list of funding bodies that supported this study can be found in the Acknowledgements section.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10878856 | PMC |
| http://dx.doi.org/10.1016/j.ebiom.2024.105019 | DOI Listing |
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