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The Psychometric Properties of the EuroQol 5D Five Level in Survivors of Critical Illness.
Crit Care Med
January 2025
Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Objectives: The EuroQol 5D five level (EQ-5D-5L) instrument is a standardized measure of health-related quality of life and is routinely used in survivors of critical illness. However, information on its psychometric properties and minimal clinically important difference (MCID) in this patient group is lacking.
Design: Secondary analysis of data from the previously published PREDICT (a registry in critically ill patients to determine predictors of disability-free survival) study, a prospective, multicenter cohort study.
Repurposing Osimertinib and Gedatolisib for Glioblastoma Treatment: Evidence of Synergistic Effects in an In Vitro Phenotypic Study.
Pharmaceuticals (Basel)
December 2024
Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio®), Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos (INCT-INOFAR), Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Glioblastoma is a malignant tumor with a poor prognosis for the patient due to its high lethality and limited chemotherapy available. Therefore, from the point of view of chemotherapy treatment, glioblastoma can be considered an unmet medical need. This has led to the investigation of new drugs for monotherapy or associations, acting by synergistic pharmacological mechanisms.
View Article and Find Full Text PDFImpact of inter-city interactions on disease scaling.
Sci Rep
January 2025
Departamento de Física, Universidade Estadual de Maringá, Maringá, PR, 87020-900, Brazil.
Inter-city interactions are critical for the transmission of infectious diseases, yet their effects on the scaling of disease cases remain largely underexplored. Here, we use the commuting network as a proxy for inter-city interactions, integrating it with a general scaling framework to describe the incidence of seven infectious diseases across Brazilian cities as a function of population size and the number of commuters. Our models significantly outperform traditional urban scaling approaches, revealing that the relationship between disease cases and a combination of population and commuters varies across diseases and is influenced by both factors.
View Article and Find Full Text PDFInfrared thermography as a non-invasive method to quantify the heat stress response in weaned piglets after road transport in a semi-arid region.
Int J Biometeorol
January 2025
Center of Agrarian Sciences, Universidade Federal do Ceará, Fortaleza, Brazil.
Heat stress (HS) is one of the main factors associated with welfare concerns during animal transport. The use of infrared thermography (IRT) for digitally monitoring HS in weaned piglets during transportation in a semi-arid region was investigated in the present study. A total of 60 focal piglets (25 ± 2.
View Article and Find Full Text PDFLacustrine sedimentation patterns at the Northern Antarctic Peninsula and surroundings as a response to late Holocene and Modern Climate changes.
Sci Rep
December 2024
Soil and Water Management & Crop Nutrition Laboratory, Joint FAO/IAEA Centre of Nuclear Techniques in Food and Agriculture, International Atomic Energy Agency, Vienna, Austria.
The Northern Antarctic Peninsula (NAP) and the West Antarctic Ice Sheet (WAIS) are likely to respond rapidly to climate changes by increasing the collapse of peripheral ice shelves and the number of days above 0 °C. These facts make this region a representative hotspot of the global sea level rise and the location of one of the global climate tipping points (thresholds in the Earth system whose changes may become irreversible, if exceeded). Understanding the climate evolution of the NAP, based on past evidences, may help infer its future scenario.
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