AI Article Synopsis
- Familial hypercholesterolemia is a genetic condition that causes high LDL cholesterol levels from birth, increasing the risk of heart disease.
- Early screening and treatment in children can significantly lower the chances of developing premature cardiovascular issues.
- Recent advancements in cholesterol-lowering therapies have made familial hypercholesterolemia manageable, with studies showing favorable outcomes and cost-effectiveness for early interventions.
Article Abstract
Purpose Of Review: Familial hypercholesterolemia leads to elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth onwards due to a pathogenetic variation in genes in cholesterol metabolism. Early screening to identify and subsequently treat children with familial hypercholesterolemia is crucial to reduce the risk of premature atherosclerotic cardiovascular disease (ASCVD). This review focuses on recent insights in the field of pediatric familial hypercholesterolemia.
Recent Findings: Screening in childhood and early initiation of optimal lipid-lowering therapy (LLT) have shown promising outcomes in the prevention of ASCVD. In addition, cost-effectiveness research has demonstrated highly favorable results. With the availability of novel therapies, familial hypercholesterolemia has become a well treatable disease.
Summary: Children with familial hypercholesterolemia benefit from early detection and optimal treatment of their elevated LDL-C levels.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11188623 | PMC |
| http://dx.doi.org/10.1097/MOL.0000000000000926 | DOI Listing |
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