AI Article Synopsis
- Researchers studied proteins in the blood called tumor markers to see how they relate to lung cancer treatment in patients who are getting chemotherapy.
- They looked at different markers in 261 patients and found that some markers like CYFRA 21-1 and CA125 could help tell if treatment was working and predict how long patients might live.
- The study showed that these blood markers are important tools for doctors to understand how well a patient is responding to treatment for non-small cell lung cancer.
Article Abstract
Background: Protein tumor markers are released in high amounts into the blood in advanced non-small cell lung cancer (NSCLC).
Objective: To investigate the relevance of serum tumor markers (STM) for prognosis, prediction and monitoring of therapy response in NSCLC patients receiving chemotherapy.
Methods: In a biomarker substudy of a prospective, multicentric clinical trial (CEPAC-TDM) on 261 advanced NSCLC patients, CYFRA 21-1, CEA, SCC, NSE, ProGRP, CA125, CA15-3 and HE4 were assessed in serial serum samples and correlated with radiological response after two cycles of chemotherapy and overall (OS) and progression-free survival (PFS).
Results: While pretherapeutic STM levels at staging did not discriminate between progressive and non-progressive patients, CYFRA 21-1, CA125, NSE and SCC at time of staging did, and yielded AUCs of 0.75, 0.70, 0.69 and 0.67 in ROC curves, respectively. High pretherapeutic CA15-3 and CA125 as well as high CYFRA 21-1, SCC, CA125 and CA15-3 levels at staging were prognostic for shorter PFS and OS -also when clinical variables were added to the models.
Conclusions: STM at the time of first radiological staging and pretherapeutic CA15-3, CA125 are predictive for first-line treatment response and highly prognostic in patients with advanced NSCLC.
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| http://dx.doi.org/10.3233/TUB-230014 | DOI Listing |
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