AI Article Synopsis
- Disrupted protein homeostasis can lead to various diseases, with the T-complex protein-1 ring complex (TRiC/CCT) being essential for protein folding, localization, and preventing aggregation.
- The review explores TRiC/CCT's role in protein folding, its mechanisms in maintaining proteostasis, and its involvement in key physiological processes, along with a detailed look at associated diseases like neuropathies and cancers.
- It concludes by highlighting gaps in current research and the need for further studies to harness TRiC/CCT's potential for clinical applications.
Article Abstract
Background: Disrupted protein homeostasis (proteostasis) has been demonstrated to facilitate the progression of various diseases. The cytosolic T-complex protein-1 ring complex (TRiC/CCT) was discovered to be a critical player in orchestrating proteostasis by folding eukaryotic proteins, guiding intracellular localisation and suppressing protein aggregation. Intensive investigations of TRiC/CCT in different fields have improved the understanding of its role and molecular mechanism in multiple physiological and pathological processes.
Main Body: In this review, we embark on a journey through the dynamic protein folding cycle of TRiC/CCT, unraveling the intricate mechanisms of its substrate selection, recognition, and intriguing folding and assembly processes. In addition to discussing the critical role of TRiC/CCT in maintaining proteostasis, we detail its involvement in cell cycle regulation, apoptosis, autophagy, metabolic control, adaptive immunity and signal transduction processes. Furthermore, we meticulously catalogue a compendium of TRiC-associated diseases, such as neuropathies, cardiovascular diseases and various malignancies. Specifically, we report the roles and molecular mechanisms of TRiC/CCT in regulating cancer formation and progression. Finally, we discuss unresolved issues in TRiC/CCT research, highlighting the efforts required for translation to clinical applications, such as diagnosis and treatment.
Conclusion: This review aims to provide a comprehensive view of TRiC/CCT for researchers to inspire further investigations and explorations of potential translational possibilities.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10870801 | PMC |
| http://dx.doi.org/10.1002/ctm2.1592 | DOI Listing |
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