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Identification of Phosphodiesterase type 5 inhibitors (PDE5is) analogues using surface-enhanced Raman scattering and machine learning algorithm.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
School of Criminal Investigation, People's Public Security University of China, Beijing 100038, China.
Phosphodiesterase type 5 inhibitors (PDE5is), primarily used for the treatment of erectile dysfunction, have been severely misused in recent years, posing a threat to public health and safety. This study developed a method that combines Surface-enhanced Raman spectroscopy (SERS) with machine learning algorithms to rapidly identify different PDE5is types. A total of 948 SERS spectra from 79 PDE5is were collected using gold nanoparticles (AuNPs) as the enhancement agent, and dimensionality reduction was performed through principal component analysis (PCA).
View Article and Find Full Text PDFValidity of prenatal AUDIT screening for alcohol disorders - a Nationwide Swedish register study.
Ups J Med Sci
December 2024
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Objective: This study aims to assess the external validity of the Alcohol Use Disorders Identification Test (AUDIT) in Swedish prenatal care as an indicator for alcohol-addiction disorders, and to characterize women with mismatched information in healthcare registers.
Design: This study was designed as a National register-based study.
Setting: Sweden.
Prolonged fever in a 13-year-old girl misdiagnosed as Ochrobactrum spp. bacteremia-the pitfalls of diagnostic Brucella spondylitis in a non-endemic country.
Folia Microbiol (Praha)
December 2024
Department of Medical Microbiology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic.
Brucellosis is a zoonosis with non-specific clinical symptoms involving multiple systems and organs. Its prevalence is low in most of EU countries, which can lead to the difficulties in laboratory and clinical diagnostic. Due to its relationship to the Ochrobactrum spp.
View Article and Find Full Text PDFTreatment Response Assessment According to Updated PROMISE Criteria in Patients with Metastatic Prostate Cancer Using an Automated Imaging Platform for Identification, Measurement, and Temporal Tracking of Disease.
Eur Urol Oncol
November 2024
Department of Radiation Oncology, University of California-Los Angeles, Los Angeles, CA, USA; Department of Radiation Oncology, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA. Electronic address:
Background And Objective: Prostate-specific membrane antigen (PSMA) molecular imaging is widely used for disease assessment in prostate cancer (PC). Artificial intelligence (AI) platforms such as automated Prostate Cancer Molecular Imaging Standardized Evaluation (aPROMISE) identify and quantify locoregional and distant disease, thereby expediting lesion identification and standardizing reporting. Our aim was to evaluate the ability of the updated aPROMISE platform to assess treatment responses based on integration of the RECIP (Response Evaluation Criteria in PSMA positron emission tomography-computed tomography [PET/CT]) 1.
View Article and Find Full Text PDFArticle Synopsis
- Platelets inherit RNA from their parent megakaryocytes and this study uses single-cell RNA sequencing to investigate the platelet transcriptome, which has not been thoroughly explored before.
- Findings revealed significant variability in gene expression among platelets, with common markers showing lower than expected abundance and highlighting that current identification methods often misclassify platelets.
- The research stresses the importance of specialized sequencing techniques for accurate platelet profiling, which could lead to advancements in understanding platelet biology and their potential use in immune therapy and as biomarkers for diseases like cancer.
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