Iron-catalyzed cascade C-C and C-O bond formation of 2,4-dienals with donor-acceptor cyclopropanes (DACs) has been developed to furnish hexahydrocyclopentapyrans. Optically active DACs can be coupled stereospecifically (>97% ee). Chirality transfer, use of iron-catalysis and substrate scope are the salient practical features.
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| http://dx.doi.org/10.1039/d3cc06261a | DOI Listing |
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