Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by a progressive cognitive decline. Sporadic AD, accounting for more than 95% of cases, may arise due to the influence of environmental factors. It was reported that periodontitis, a common oral ailment, shares several risk factors with AD, including advanced age, smoking, diabetes, and hypertension, among others. Periodontitis is an inflammatory disease triggered by dysbiosis of oral microorganisms, whereas Alzheimer's disease is characterized by neuroinflammation. Many studies have indicated that chronic inflammation can instigate brain AD-related pathologies, including amyloid-β plaques, Tau protein hyperphosphorylation, neuroinflammation, and neurodegeneration. The potential involvement of periodontal pathogens and/or their virulence factors in the onset and progression of AD by the oral-brain axis has garnered significant attention among researchers with ongoing investigations. This review has updated the periodontal pathogens potentially associated with AD, elucidating their impact on the central nervous system, immune response, and related pathological processes in the brain to provide valuable insights for future research on the oral-brain axis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868393 | PMC |
| http://dx.doi.org/10.3389/fmicb.2024.1358179 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cannabis use, oral dysbiosis, and neurological disorders.
NeuroImmune Pharm Ther
September 2024
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Cannabis (marijuana) is a leafy plant that has medical, recreational, and other uses. Cannabis is socially accepted and widely used throughout the United States. Though cannabis use is increasingly gaining popularity, studies detail the deleterious effects of chronic cannabis smoking on mental health, as well as the immunosuppressive properties of cannabinoids.
View Article and Find Full Text PDFStress and mental health symptoms in early pregnancy are associated with the oral microbiome.
BMJ Ment Health
November 2024
Department of Psychology, Michigan State University, East Lansing, Michigan, USA
Background: Research has revealed associations between microbes of the gastrointestinal tract and stress, anxiety and depression in pregnant or postpartum women. While these studies suggest a gut-brain-behaviour axis, no studies have examined microbes of the oral cavity in relation to maternal mental health.
Objective: To explore a potential oral-brain-behaviour axis related to maternal mental health.
The association between oral diseases and neurodegenerative disorders.
J Alzheimers Dis
December 2024
Institute of Dentistry, Medical School, University of Eastern Finland, and Oral and Maxillofacial Teaching Unit, Kuopio University Hospital, Kuopio, Finland.
Article Synopsis
- The study reviewed recent literature on the connection between oral diseases, particularly periodontitis, and cognitive neurodegenerative diseases like Alzheimer's.
- The research highlighted significant links especially in older adults who have other risk factors, showing worse oral health correlating with higher neurodegenerative disease risk.
- It concluded that maintaining good oral health might help prevent or lessen the risks associated with neurodegenerative diseases.
Probing the oral-brain connection: oral microbiome patterns in a large community cohort with anxiety, depression, and trauma symptoms, and periodontal outcomes.
Transl Psychiatry
October 2024
Department of Pharmacology and Toxicology, Faculty of Medicine, University Complutense Madrid (UCM), Madrid, Spain.
The role of the oral microbiome in mental health has recently been appreciated within the proposed oral-brain axis. This study examined the structure and composition of the salivary microbiome in a large-scale population-based cohort of individuals reporting mental health symptoms (n = 306) compared to mentally healthy controls (n = 164) using 16S rRNA sequencing. Mental health symptoms were evaluated using validated questionnaires and included depression, anxiety, and posttraumatic stress disorder (PTSD), with accompanying periodontal outcomes.
View Article and Find Full Text PDFRelationship between human oral microbiome dysbiosis and neuropsychiatric diseases: An updated overview.
Behav Brain Res
August 2024
Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China. Electronic address:
The role of the gut-brain axis in mental health disorders has been extensively studied. As the oral cavity is the starting point of the digestive tract, the role that the oral microbiota plays in mental health disorders has gained recent attention. Oral microbiota can enter the bloodstream and trigger inflammatory responses or translocate to the brain through the trigeminal nerve or olfactory system.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!