Hydrogen sulfide (HS) is a toxic, essential gas used in various biological and physical processes and has been the subject of many targeted studies on its role as a new gas transmitter. These studies have mainly focused on the production and pharmacological side effects caused by HS. Therefore, effective strategies to remove HS has become a key research topic. Furthermore, the development of novel nanoplatforms has provided new tools for the targeted removal of HS. This paper was performed to review the association between HS and disease, related HS inhibitory drugs, as well as HS responsive nanoplatforms (HRNs). This review first analyzed the role of HS in multiple tissues and conditions. Second, common drugs used to eliminate HS, as well as their potential for combination with anticancer agents, were summarized. Not only the existing studies on HRNs, but also the inhibition HS combined with different therapeutic methods were both sorted out in this review. Furthermore, this review provided in-depth analysis of the potential of HRNs about treatment or detection in detail. Finally, potential challenges of HRNs were proposed. This study demonstrates the excellent potential of HRNs for biomedical applications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10867614 | PMC |
| http://dx.doi.org/10.1016/j.ajps.2023.100858 | DOI Listing |
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