AI Article Synopsis

  • This study compared changes in pigment epithelium detachment composition indices (PEDCI-F) in patients with neovascular age-related macular degeneration (n-AMD) and polypoidal choroidal vasculopathy (PCV) over one year.
  • The research involved analyzing optical coherence tomography (OCT) images from 74 eyes (36 with n-AMD and 38 with PCV) treated with anti-VEGF agents, focusing on the composition and changes in PED lesions at 3, 6, and 12 months.
  • The findings showed a slight increase in PEDCI-F in both conditions, with higher levels linked to improved visual acuity and fewer necessary anti-VEGF injections, suggesting different

Article Abstract

Purpose: To compare changes in the fibrous component of pigment epithelium detachment composition indices (PEDCI-F) in neovascular age-related macular degeneration (n-AMD) and polypoidal choroidal vasculopathy (PCV) over 12 months.

Methods: This was a retrospective chart review of treatment-naïve n-AMD and PCV eyes treated with anti-vascular endothelial growth factor (anti-VEGF) agents. Optical coherence tomography (OCT) images were recorded at baseline and at 3, 6, and 12 months. OCT images were processed by filtering followed by pigment epithelium detachment (PED) segmentation and analysis of PED lesion heterogeneity based on the composition (PEDCI-F).

Results: A total of 74 eyes with n-AMD (36) and PCV (38) were included. Overall, PEDCI-F increased minimally in both n-AMD and PCV groups (both p > 0.05). The majority, i.e., 58.3% and 60.5%, of n-AMD and PCV eyes, respectively, showed an increase in PEDCI-F at 12 months. An increase in PEDCI-F was associated with improved BCVA logMAR (n-AMD, r = -0.79; p < 0.001 and PCV, r = - 0.06; p = 0.74) and the need for fewer anti-VEGF injections (n-AMD, r = - 0.53; p < 0.001 and PCV, r = - 0.09; p = 0.58).

Conclusion: PEDCI-F increases in the majority of eyes with n-AMD and PCV through 12 months following treatment with anti-VEGF injections. This group had better visual acuity compared to the other subset with reduction in PEDCI-F requiring more anti-VEGF injections and worse visual acuity, possibly due to fibrovascular PED (FVPED) collapse and atrophy or a relative increase in other PEDCI constituents at 12 months.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868073PMC
http://dx.doi.org/10.1186/s40942-023-00512-6DOI Listing

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Article Synopsis
  • This study compared changes in pigment epithelium detachment composition indices (PEDCI-F) in patients with neovascular age-related macular degeneration (n-AMD) and polypoidal choroidal vasculopathy (PCV) over one year.
  • The research involved analyzing optical coherence tomography (OCT) images from 74 eyes (36 with n-AMD and 38 with PCV) treated with anti-VEGF agents, focusing on the composition and changes in PED lesions at 3, 6, and 12 months.
  • The findings showed a slight increase in PEDCI-F in both conditions, with higher levels linked to improved visual acuity and fewer necessary anti-VEGF injections, suggesting different
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Vitreoretinal Society of India practice pattern survey 2020: Medical retina.

Indian J Ophthalmol

June 2021

Vitreoretinal Society of India (VRSI); Suven Clinical Research Center, LV Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: The aim of this study was to present the outcomes of the Vitreo-retinal Society of India (VRSI) Practice Pattern Survey 2020 in medical retina.

Methods: An online survey of members of VRSI was conducted in April 2020 regarding their practice-patterns on varied medical and surgical retina topics concerning imaging and management approach. The results were evaluated by two independent experts in this field and compared with the evidence and other practice patterns in the world.

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