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Particulate matter from car exhaust alters function of human iPSC-derived microglia. | LitMetric

AI Article Synopsis

  • Air pollution, particularly from traffic-related particulate matter, is linked to cognitive decline and neurodegenerative diseases, with potential direct invasion of the brain causing inflammation.* -
  • Research found that exposure to two types of particulate matter from diesel and compressed natural gas altered the function of human microglia-like cells, affecting their survival and inflammatory responses.* -
  • The study highlights the need for further investigation into how these changes in microglia due to air pollution may impact brain health and cognitive functions over time, using human-derived microglia for future research.*

Article Abstract

Background: Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer's disease. Inhaled components of PM may directly invade the brain via the olfactory route, or act through peripheral system responses resulting in inflammation and oxidative stress in the brain. Microglia are the immune cells of the brain implicated in the progression of neurodegenerative diseases. However, it remains unknown how PM affects live human microglia.

Results: Here we show that two different PMs derived from exhausts of cars running on EN590 diesel or compressed natural gas (CNG) alter the function of human microglia-like cells in vitro. We exposed human induced pluripotent stem cell (iPSC)-derived microglia-like cells (iMGLs) to traffic related PMs and explored their functional responses. Lower concentrations of PMs ranging between 10 and 100 µg ml increased microglial survival whereas higher concentrations became toxic over time. Both tested pollutants impaired microglial phagocytosis and increased secretion of a few proinflammatory cytokines with distinct patterns, compared to lipopolysaccharide induced responses. iMGLs showed pollutant dependent responses to production of reactive oxygen species (ROS) with CNG inducing and EN590 reducing ROS production.

Conclusions: Our study indicates that traffic-related air pollutants alter the function of human microglia and warrant further studies to determine whether these changes contribute to adverse effects in the brain and on cognition over time. This study demonstrates human iPSC-microglia as a valuable tool to study functional microglial responses to environmental agents.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10870637PMC
http://dx.doi.org/10.1186/s12989-024-00564-yDOI Listing

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