Background: Hand disorders are common in menopausal women. Equol is a soy metabolite produced in humans and its production level differs among individuals. The purpose of this research is to investigate the correlative relationship between variables indicating equol production levels and the occurrence of hand disorders in menopausal and postmenopausal women.
Methods: Female subjects were divided into two groups: women 45-70 years of age with hand osteoarthritis (patient group) and women in the same age range without hand osteoarthritis (control group). The equol production level of each subject was estimated by measuring her urine equol concentration. We also surveyed the subjects' family histories of osteoarthritis.
Results: Equol levels in the patient group were significantly lower than those in the control group (p < 0.05). This difference was most apparent for women in their 50s. Individuals with family histories of Heberden's and Bouchard's nodes were found to be 48.1 times more likely to develop these conditions than individuals in the control group.
Conclusions: Women with early menopausal hand symptoms (i.e., stiff and arthritic hands) often develop hand osteoarthritis during their late menopausal and postmenopausal periods, which may cause their QoL to significantly deteriorate. Although a link between the probability of women developing hand osteoarthritis and their clinical backgrounds (i.e., family history) had been suspected, it had not been thoroughly investigated. Our survey of women with and without Heberden's nodes and Bouchard's nodes found a significant correlation between the likelihood of women developing osteoarthritis and a family history of this disease. We also found a significant correlation between the likelihood of women developing hand osteoarthritis and their equol production levels. These results indicate that women with family histories of finger osteoarthritis and low equol production have higher risks of developing finger osteoarthritis.
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Equol promotes the in vitro maturation of porcine oocytes by activating the NRF2/KEAP1 signaling pathway.
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College of Animal Science & Technology, Guangxi University, Nanning, Guangxi, 530004, China; Guangxi Key Laboratory of Animal Breeding & Disease Control and Prevention, Guangxi University, Nanning, Guangxi, 530004, China. Electronic address:
Article Synopsis
- The study focuses on how equol, an antioxidant derived from soybean flavonoids, impacts the in vitro maturation (IVM) of porcine oocytes, which are often affected by oxidative stress and reactive oxygen species (ROS).
- Results show that 5 μM equol improves oocyte quality by enhancing cumulus cell expansion, polar body extrusion, and embryonic development post-activation, alongside boosting mitochondrial function and lipid accumulation.
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Chitin promotes equol production via n-acetylglucosamine in human fecal cultures.
Anaerobe
November 2024
Gifu Prefectural Research Institute for Food Science, 1-1 Yanagido, Gifu, 501-1112, Japan. Electronic address:
Objectives: Equol is a metabolite of isoflavone. Here, we investigated the effect of dietary fiber on equol-producing microbiota.
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Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Crta de la Coruña Km7.5, 28040 Madrid, Spain. Electronic address:
Equol and 5-hydroxy-equol, and their analogous compounds dehydroequol and 5-hydroxy-dehydroequol, are bioactive isoflavones formed by microbial metabolism. The aims of this work were to elucidate the formation of dehydroequol and 5-hydroxy-dehydroequol, to identify the role of dihydrodaidzein reductase (DHDR) in the production of equol, dehydroequol, 5-hydroxy-equol and 5-hydroxy-dehydroequol and to develop soy beverages enriched in these compounds through engineered lactic acid bacteria. DHDR was responsible for the production of equol and dehydroequol from dihydrodaidzein (DHD), and of 5-hydroxy-equol and 5-hydroxy-dehydroequol from dihydrogenistein (DHG), even in the absence of tetrahydrodaidzein reductase (THDR).
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Ural Federal University named after the first President of Russia B. N. Yeltsin, 19 Mira Street, Yekaterinburg 620002, Russia.
A series of 16 (hetero)aryl compounds based on coumarin and equol has been efficiently synthesized by exploring the palladium-catalyzed Suzuki cross-coupling reactions. Polyphenol based on coumarin (4-methyl-7-hydroxy coumarin) was initially converted to corresponding coumarin imidazylate and then subjected to Suzuki coupling reaction with 4-methoxyphenylboronic acid to obtain the coupled product. This modified approach was later developed into a one-pot methodology by directly reacting the polyphenol with 1,1-sulfonyldiimidazole (SDI) and boronic acid in situ to obtain the Suzuki coupled product in one step.
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Department of Neurology, National Cerebral and Cardiovascular Center, 6-1, Kishibe-shimmachi, Suita 564-8565, Japan.
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