Plant mitochondrial and plastid genomes typically show pervasive, genome-wide transcription. Little is known, however, about the utility of organelle noncoding RNAs, which often make up most of the transcriptome. Here, we suggest that long-read sequencing data combined with dedicated RNA databases could help identify putative functional organelle noncoding transcripts.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tplants.2024.01.004DOI Listing

Publication Analysis

Top Keywords

organelle noncoding
8
pervasive transcription
4
transcription plant
4
plant organelle
4
organelle genomes
4
genomes functional
4
functional noncoding
4
noncoding transcriptomes?
4
transcriptomes? plant
4
plant mitochondrial
4

Similar Publications

DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer.

Cell Death Dis

January 2025

Tianjian Laboratory of Advanced Biomedical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.

Mitochondrial oxidative phosphorylation (OXPHOS) is a therapeutic vulnerability in glycolysis-deficient cancers. Here we show that inhibiting OXPHOS similarly suppresses the proliferation and tumorigenicity of glycolytically competent colorectal cancer (CRC) cells in vitro and in patient-derived CRC xenografts. While the increased glycolytic activity rapidly replenished the ATP pool, it did not restore the reduced production of aspartate upon OXPHOS inhibition.

View Article and Find Full Text PDF

C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity.

Cell Rep

January 2025

Institute of Chemistry, Academia Sinica, Taipei 115, Taiwan; Sustainable Chemical Science and Technology, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan; Department of Applied Chemistry, National Chiayi University, Chiayi City 600, Taiwan; Neuroscience Program of Academia Sinica, Academia Sinica, Taipei 115, Taiwan. Electronic address:

The toxicity of C9ORF72-encoded polyproline-arginine (poly-PR) dipeptide is associated with its ability to disrupt the liquid-liquid phase separation of intrinsically disordered proteins participating in the formation of membraneless organelles, such as the nucleolus and paraspeckles. Amyotrophic lateral sclerosis (ALS)-related TAR DNA-binding protein 43 (TDP-43) also undergoes phase separation to form nuclear condensates (NCs) in response to stress. However, whether poly-PR alters the nuclear condensation of TDP-43 in ALS remains unclear.

View Article and Find Full Text PDF

CircRNAs in extracellular vesicles associated with triple-negative breast cancer.

Cell Mol Biol (Noisy-le-grand)

January 2025

Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh-11623, Saudi Arabia.

Article Synopsis
  • Triple-negative breast cancer (TNBC) is an aggressive form of cancer that often spreads to distant sites in the body, and understanding how it metastasizes is crucial for treatment.
  • Exosomes, which are small extracellular vesicles that carry RNA molecules, play a significant role in TNBC metastasis and present new opportunities for diagnosing and treating the disease via liquid biopsy.
  • Circular RNAs (circRNAs), a subtype of noncoding RNAs found in exosomes, can influence gene expression and are abundant in EVs; they may enhance communication between cancer cells, thereby influencing TNBC progression and offering potential biomarkers for prognosis and monitoring.
View Article and Find Full Text PDF

Myocardial infarction (MI) is a highly challenging and fatal disease, with diverse challenges arising at different stages of its progression. As such, non-coding RNAs (ncRNAs), which can broadly regulate cell fate, and stem cells with multi-differentiation potential are emerging as novel therapeutic approaches for treating MI across its various stages. NcRNAs, including microRNAs (miRNAs) and long non-coding RNAs (LncRNAs), can directly participate in regulating intracellular signaling pathways, influence cardiac angiogenesis, and promote the repair of infarcted myocardium.

View Article and Find Full Text PDF

Small nucleolar RNAs (snoRNAs) are non-coding RNAs (ncRNAs) that regulate many cellular processes. Changes in the profiles of cellular ncRNAs and those secreted in exosomes are observed during viral infection. In our study, we analysed differences in expression profiles of snoRNAs isolated from exosomes of influenza (IAV)-infected and non-infected MDCK cells using high-throughput sequencing.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!