Rat platelets and the corresponding rabbit IgG antibodies mixed in polyester sponges implanted under the skin of normal animals caused an enhanced 24-h inflammatory response and a significant increase of prostaglandins in the exudate. These experimental results contrast with those obtained for normal rats implanted with sponges containing only IgG anti-platelet antibodies. The present experiments show that circulating platelets were not concentrated at the inflamed site and can hardly be considered of importance in acute inflammation.
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