Human milk oligosaccharide (HMO) consumption by the infant microbiota is positively associated with immune health. In this issue of Cell Host & Microbe, Buzun et al. report a mechanism for HMO digestion by Bacteroides fragilis and demonstrate how the same pathway works on intestinal mucus to establish long-term gut residency.
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| http://dx.doi.org/10.1016/j.chom.2024.01.007 | DOI Listing |
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View Article and Find Full Text PDFGut microbiota: A key role for human milk oligosaccharides in regulating host health early in life.
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Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, Harbin, China.
Human milk oligosaccharides (HMOs) are an evolutionarily significant advantage bestowed by mothers for facilitating the development of the infant's gut microbiota. They can avoid absorption in the stomach and small intestine, reaching the colon successfully, where they engage in close interactions with gut microbes. This process also enables HMOs to exert additional prebiotic effects, including regulating the mucus layer, promoting physical growth and brain development, as well as preventing and mitigating conditions such as NEC, allergies, and diarrhea.
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