AI Article Synopsis
- Parkinson's disease (PD) is marked by the presence of Lewy bodies, which are made up of a protein called α-synuclein, and there is evidence suggesting that extracellular vesicles (EVs) help spread this pathology in the nervous system.
- In a study analyzing serum EVs from various groups (including PD patients and healthy controls), researchers found a significant drop in EV numbers in PD patients, but an increase in filamentous α-synuclein within these EVs, indicating a potential link to the disease.
- The results suggest that serum α-synuclein filaments in EVs could serve as useful diagnostic markers for diseases related to α-synuclein, and they highlight the role of EV
Article Abstract
Parkinson's disease (PD) is characterized by the pathological deposition of a-synuclein (a-syn) inclusions, known as Lewy bodies/neurites. Emerging evidence suggests that extracellular vesicles (EVs) play a role in facilitating the spreading of Lewy pathology between the peripheral nervous system and the central nervous system. We analyzed serum EVs obtained from patients with PD (n = 142), multiple system atrophy (MSA) (n = 18), progressive supranuclear palsy (PSP) (n = 28), rapid eye movement sleep behavior disorder (n = 31), and controls (n = 105). While we observed a significant reduction in the number of EVs in PD compared to controls (p = 0.006), we also noted a substantial increase in filamentous α-synuclein within EVs in PD compared to controls (p < 0.0001), MSA (0.012), and PSP (p = 0.03). Further analysis unveiled the role of EVs in facilitating the transmission of filamentous α-synuclein between neurons and from peripheral blood to the CNS. These findings highlight the potential utility of serum α-synuclein filaments within EVs as diagnostic markers for synucleinopathies and underscore the significance of EVs in promoting the dissemination of filamentous α-synuclein throughout the entire body.
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| http://dx.doi.org/10.1016/j.bbrc.2024.149620 | DOI Listing |
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