AI Article Synopsis
- - An elderly woman with light chain myeloma experienced severe nosebleeds and significant bruising due to abnormal blood clotting factors and low fibrinogen levels.
- - Her lab results showed a very high kappa/lambda ratio, indicative of her myeloma, and abnormal results in various coagulation tests.
- - Despite the diagnosis, the patient declined treatment and ultimately passed away from progressive renal failure, highlighting the rare combination of Factor X and Factor V deficiencies alongside acquired dysfibrinogenemia.
Article Abstract
An elderly woman with light chain myeloma presented with prolonged epistaxis and extensive cutaneous haematomas: her kappa/lambda ratio was high at 395, her coagulation screen, thrombin and reptilase times were abnormal, her FV and FX were in the low range in the absence of specific inhibitors, her Clauss fibrinogen was low at 0.95 g/l but antigenic FNG was 1.58 g/l. The patient denied treatment and died of progressive renal failure. We wish to describe the unusual association of FX and FV deficiency co-existing with an acquired dysfibrinogenaemia.
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| http://dx.doi.org/10.1097/MBC.0000000000001280 | DOI Listing |
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