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| http://dx.doi.org/10.1113/EP091733 | DOI Listing |
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Diminished attention network activity and heightened salience-default mode transitions in generalized anxiety disorder: Evidence from resting-state EEG microstate analysis.
J Affect Disord
December 2024
Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, People's Republic of China; Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, Tianjin, People's Republic of China; Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration, Tianjin, People's Republic of China. Electronic address:
Generalized anxiety disorder (GAD) is a common anxiety disorder characterized by excessive, uncontrollable worry and physical symptoms such as difficulty concentrating and sleep disturbances. Although functional magnetic resonance imaging (fMRI) studies have reported aberrant network-level activity related to cognition and emotion in GAD, its low temporal resolution restricts its ability to capture the rapid neural activity in mental processes. EEG microstate analysis offers millisecond-resolution for tracking the dynamic changes in brain electrical activity, thereby illuminating the neurophysiological mechanisms underlying the cognitive and emotional dysfunctions in GAD.
View Article and Find Full Text PDFEvolution of the medium-term functional outcomes of holmium laser prostate enucleation (HoLEP).
Fr J Urol
December 2024
Clinique Trenel Sainte-Colombe, France.
Introduction: The boom in surgery for benign prostatic hyperplasia using Holmium laser enucleation (HoLEP) has reduced length of hospitalization, catheterization duration and the risk of bleeding, with comparable results to the old gold standard. The aim of this study is to evaluate the evolution of medium-term functional results after HoLEP.
Method: Retrospective monocentric observational study in patients who underwent HoLEP surgery from 2014 to 2019.
Objective: The purpose of this study was to evaluate the effectiveness of the drugs Solifenacin and Vesusten in relation to the treatment of neurogenic bladder overactivity in multiple sclerosis (MS).
Materials And Methods: A prospective, single-site, single-center, placebo-controlled, parallel-group, comparative clinical trial was conducted. The study included 41 MS patients of both sexes aged 18-50 years with urodynamically confirmed detrusor overactivity.
Placental gene therapy in nonhuman primates: a pilot study of maternal, placental, and fetal response to non-viral, polymeric nanoparticle delivery of IGF1.
Mol Hum Reprod
November 2024
Department of Physiology and Aging, College of Medicine, University of Florida, Gainesville, FL, USA.
Currently, there are no placenta-targeted treatments to alter the in utero environment for administration to pregnant women who receive a diagnosis of fetal growth restriction (FGR). Water-soluble polymers have a distinguished record of clinical relevance outside of pregnancy. We have demonstrated the effective delivery of polymer-based nanoparticles containing a non-viral human insulin-like growth factor 1 (IGF1) transgene to correct placental insufficiency in small animal models of FGR.
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