Introduction: Pragmatic research studies that include diverse dyads of persons living with dementia (PLWD) and their family caregivers are rare.
Methods: Community-dwelling dyads were recruited for a pragmatic clinical trial evaluating three approaches to dementia care. Four clinical trial sites used shared and site-specific recruitment strategies to enroll health system patients.
Results: Electronic health record (EHR) queries of patients with a diagnosis of dementia and engagement of their clinicians were the main recruitment strategies. A total of 2176 dyads were enrolled, with 80% recruited after the onset of the pandemic. PLWD had a mean age of 80.6 years (SD 8.5), 58.4% were women, and 8.8% were Hispanic/Latino, and 11.9% were Black/African American. Caregivers were mostly children of the PLWD (46.5%) or spouses/partners (45.2%), 75.8% were women, 9.4% were Hispanic/Latino, and 11.6% were Black/African American.
Discussion: Health systems can successfully enroll diverse dyads in a pragmatic clinical trial.
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http://dx.doi.org/10.1002/alz.13698 | DOI Listing |
Dementia (London)
January 2025
Department of Psychology, University of Wisconsin Oshkosh, Oshkosh, WI, USA.
Dementia and the associated stigma pose unique threats to the identity of persons with dementia, triggering attempts to cope with resulting identity changes. We explore identity change narratives and metaphors written by people with dementia and care partners in public blog posts. These metaphors reflect bloggers' motivation to adapt, adjust, and cope with identity change and their motives to challenge common misunderstandings of dementia as a complete loss of selfhood.
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January 2025
Health Care Research Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Greifswald Mecklenburg-Vorpommern Germany.
Introduction: This study investigated the association between modifiable factors and symptom progression in dementia over up to 8 years.
Methods: Multilevel growth curve models assessed the role of modifiable risk factors (low education, hearing impairment and its treatment, depression, physical inactivity, diabetes and its treatment, smoking, hypertension and its treatment, obesity, alcohol consumption, social isolation, and visual impairment) on cognitive and functional trajectories in 353 people with dementia.
Results: Higher education was associated with higher initial cognitive status but faster decline.
iScience
January 2025
School of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.
TWIK-1 belongs to the two-pore domain K (K2P) channel family, which plays an essential role in the background K conductance of cells. Despite the development of exon 2-deleted knockout (KO) mice, the physiological role of TWIK-1 has remained largely unknown. Here, we observed that the exon 2-deleted KO mice expressed an internally deleted TWIK-1 (TWIK-1 ΔEx2) protein, which unexpectedly acts as a functional K channel.
View Article and Find Full Text PDFHealth Aff Sch
January 2025
Department of Family Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States.
The rapid rise in numbers of people living with Alzheimer's disease and related disorders (ADRD) poses major challenges to health systems and policy. Although primary care clinicians provide ongoing medical care for 80% of affected individuals, they face persistent barriers to providing high-quality dementia care. We conducted qualitative interviews with family physicians ( = 20) to understand what core outcomes they consider most important and what care processes and systems and policy strategies they propose to achieve them.
View Article and Find Full Text PDFHealth Aff Sch
January 2025
Health Workforce Technical Assistance Center, Center for Health Workforce Studies, College of Integrated Health Sciences, University at Albany, State University of New York, Rensselaer, NY 12144, United States.
The health workforce is an essential component of our health care delivery system. A well-trained, sufficiently sized, and diverse workforce is critical to meet the health care needs of the population. However, in this postpandemic era, many challenges persist.
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