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Relation of thumb-palm test with ascending aortic diameter and aortic regurgitation.
Acta Cardiol
November 2024
Faculty of Medicine, Cardiology, İstanbul Nişantaşı University, İstanbul, Turkey.
Accuracy of the "Thumb-Palm Test" for Detection of Ascending Aortic Aneurysm.
Am J Cardiol
July 2021
Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut. Electronic address:
We have noticed, in caring for thousands of patients with ascending aortic aneurysm (AscAA), that the "thumb palm test" is often positive (with the thumb crossing beyond the edge of the palm). It is not known how accurate this test may be. We conducted the thumb-palm test in 305 patients undergoing cardiac surgery with intra-operative transesophageal echocardiography (TEE) for a variety of disorders: ascending aneurysm in 59 (19.
View Article and Find Full Text PDFGuilt by association: a paradigm for detection of silent aortic disease.
Ann Cardiothorac Surg
May 2016
1 Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, CT, USA ; 2 Department of Surgical Diseases # 2, Kazan State Medical University, Kazan, Russia.
Detection of clinically silent thoracic aortic aneurysm (TAA) is challenging due to the lack of symptoms (until aortic rupture or dissection occurs). A large proportion of TAA are identified incidentally while imaging a patient for other reasons. However, recently several clinical "associates" of TAA have been described that can aid in identification of silent TAA.
View Article and Find Full Text PDFMutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity.
FEBS J
March 2016
Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Ubiquitin-specific protease (USP)1 is a member of the USP family of deubiquitinating enzymes. Efficient USP1 activity requires binding to its cofactor USP1-associated factor 1 (UAF1), and the USP1-UAF1 deubiquitinase complex has important roles in regulating DNA damage-related processes. USPs show common folding of their catalytic domain, with three subdomains termed Thumb, Palm, and Fingers.
View Article and Find Full Text PDFParadigm for Detecting Silent Thoracic Aneurysm Disease.
Semin Thorac Cardiovasc Surg
July 2017
Aortic Institute at Yale-New Haven Hospital, Yale University School of Medicine, New Haven, Connecticut; Department of Surgical Diseases #2, Kazan State Medical University, Kazan, Russia.
Thoracic aortic aneurysms (TAA) pose a serious detection challenge owing to their clinically silent nature. Only a small fraction of TAAs cause symptoms in patients. However, the mortality burden of this disease in the population is significant, given the high lethality of such complications as aortic rupture and dissection.
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