AI Article Synopsis
- Enterohemorrhagic E. coli (EHEC) is a serious pathogen linked to foodborne illnesses, causing various health issues including diarrhea and haemolytic uraemic syndrome.
- Unique genomic islands, known as O islands (OIs), in EHEC O157:H7 contain key genes not found in non-pathogenic strains and are vital for the bacteria's traits.
- This review highlights research on regulatory proteins encoded by these O islands, focusing on their roles in EHEC's virulence, movement, and resistance to acidic environments, which is important for understanding the pathogen's impact.
Article Abstract
Enterohemorrhagic (EHEC) is an important zoonotic pathogen that is a major cause of foodborne diseases in most developed and developing countries and can cause uncomplicated diarrhoea, haemorrhagic colitis, and haemolytic uraemic syndrome. O islands (OIs), which are unique genomic islands in EHEC O157:H7, are composed of 177 isolated genomic features and harbour 26% of the total genes that are absent in the non-pathogenic K-12 genome. In the last twenty years, many OI-encoded proteins have been characterized, including proteins regulating virulence, motility, and acid resistance. Given the critical role of regulatory proteins in the systematic and hierarchical regulation of bacterial biological processes, this review summarizes the OI-encoded regulatory proteins in EHEC O157:H7 characterized to date, emphasizing OI-encoded regulatory proteins for bacterial virulence, motility, and acid resistance. This summary will be significant for further exploration and understanding of the virulence and pathogenesis of EHEC O157:H7.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10877973 | PMC |
| http://dx.doi.org/10.1080/21505594.2024.2313407 | DOI Listing |
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