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Serum zinc concentration in patients with myocardial infarction: a retrospective study. | LitMetric

Serum zinc concentration in patients with myocardial infarction: a retrospective study.

BMC Cardiovasc Disord

Department of Cardiology, Sendai City Medical Center, Sendai Open Hospital, 5-22-1 Tsurugaya, Miyagino-ku, Sendai, 983-0824, Japan.

Published: February 2024

Background: Zinc regulates the oxidative stress and inflammatory signaling cascade and affects the development and deterioration of cardiovascular disease. We investigated the prognosis of developing heart failure in patients with myocardial infarction.

Methods: Patients with myocardial infarction (n = 243) were divided using the median value of zinc concentration on admission into low (< 66 µg/dL at admission, n = 111) and high zinc group (≥ 66 µg/dL at admission, n = 132). During follow-up (mean ± SD: 734 ± 597 days; median 691 days), admission due to heart failure was observed in 12 patients: 10 and 2 cases in the low and high zinc groups, respectively.

Results: The risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.0043). Relative to the high zinc group, the hazard ratio for admission due to heart failure was 15.7 (95% confidence interval 1.11-221, P = 0.042) via adjusted Cox proportional hazards analysis. Even after propensity score matching, the risk of admission due to heart failure was significantly higher in the low zinc than in the high zinc group (P = 0.048).

Conclusion: Low serum zinc concentration may be a risk factor for admission due to heart failure after myocardial infarction.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10865534PMC
http://dx.doi.org/10.1186/s12872-024-03776-4DOI Listing

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