Mammalian cells react to the accumulation of double-stranded (ds)DNA in the cytosol by secreting antiviral and proinflammatory cytokines, notably type I interferon (IFN). Recent data reported by Tani et al. demonstrate that overactivation of this pathway is prevented by an adaptive feedback mechanism elicited by type I IFN receptors and executed by the exonuclease three prime repair exonuclease 1 (TREX1).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11075008 | PMC |
| http://dx.doi.org/10.1016/j.trecan.2024.02.001 | DOI Listing |
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