The general conclusions from the Collaborative Behavioral Teratology Study (CBTS) and the implications for research and testing in the field of behavioral teratology are discussed. The results of the CBTS indicate that behavioral teratology data are reproducible, if appropriate attention to study design and testing procedures is maintained. The statistical detection sensitivity of most of the test procedures was excellent, requiring no more than a 5-20% change from control values to detect an effect. Litter, gender and early testing experience may contribute significant variation and should be controlled in any testing situation. The application of behavioral teratology testing and the regulatory role of data for hazard assessment and risk estimation to the human population are discussed. Future research needs were identified from the CBTS workshop discussions.
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Alcohol Clin Exp Res (Hoboken)
December 2024
Department of Psychology, Center for Behavioral Teratology, San Diego State University, San Diego, California, USA.
Background: Fine motor skill deficits have been reported for children with histories of prenatal alcohol exposure, but little is known whether impaired motor skill extends to the regulation of precision grip control.
Methods: Children with (n = 15) and without (n = 17) histories of heavy prenatal alcohol exposure used their dominant hand to grasp, lift, and hold in space a small-instrumented object with a mass of 19 g. Object mass was also experimentally increased by separately adding two aluminum cubes with mass of 200 and 400 g.
Sci Rep
December 2024
Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy, Institute of Clinical Pharmacology and Toxicology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
Because of their developmental toxicity, some antiseizure medication (ASM) should be avoided during pregnancy. This may lead to discontinuation or switching of ASM after recognition of pregnancy, but some of these changes may be suboptimal. Trends in ASM use at conception were analyzed in 3,763 pregnancies prospectively ascertained by a teratology information service in Germany between 2000 and 2018.
View Article and Find Full Text PDFStem Cell Res Ther
December 2024
Key Laboratory of Experimental Teratology of the Ministry of Education, Department of Medical Genetics, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Background: The hippocampus is associated with mood disorders, and the activation of quiescent neurogenesis has been linked to anxiolytic effects. Near-infrared (NIR) light has shown potential to improve learning and memory in human and animal models. Despite the vast amount of information regarding the effect of visible light, there is a significant gap in our understanding regarding the response of neural stem cells (NSCs) to NIR stimulation, particularly in anxiety-like behavior.
View Article and Find Full Text PDFJAMA Netw Open
December 2024
Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Importance: In pregnancy, the benefits of lithium treatment for relapse prevention in psychiatric conditions must be weighed against potential teratogenic effects. Currently, there is a paucity of information on how and when lithium is used by pregnant women.
Objective: To examine lithium use in the perinatal period.
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