AI Article Synopsis
- Human milk contains milk fat globule membrane proteins (MFGMP) that support infant health, and variations in these proteins are observed in women with gestational diabetes mellitus (GDM).
- This study compares the MFGMP of GDM and non-GDM (NGDM) women over three months postpartum using advanced proteomics technology, revealing significant differences between the two groups.
- A total of 4747 MFGMP were identified, with 174 proteins showing differential expression; notably, albumin and transthyretin were significantly higher in GDM mothers, suggesting ongoing issues with insulin resistance and glucose metabolism postpartum.
Article Abstract
Milk fat globule membrane proteins (MFGMP) in human milks have positive effects on infant's health. As gestational diabetes mellitus (GDM) causes variations in MFGMP, it is essential to understand the effects of GDMon MFGMP. This study aims to investigate and compare the MFGMP (>3 months postpartum) of GDM and non-GDM (NGDM) women using four-dimensional-data-independent-acquisition proteomics technology. Principal component analysis shows significant differences in the MFGMP of GDM and NGDM women. A total of 4747 MFGMP were identified in maturehuman milk of GDM and NGDM women. Among these proteins, 174 differentially expressed proteins (DEPs) were identified in MFGM of GDM and NGDM women. Albumin (FC = 7.96) and transthyretin (FC = 2.57) which are related to insulin resistance and involved in thyroid hormone synthesis, are significantly up-regulated in MFGMP of GDM mothers indicating insulin resistance, imbalance of glucose homeostasis and poor glucose metabolism might persist in postpartum period.
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| http://dx.doi.org/10.1016/j.foodchem.2024.138691 | DOI Listing |
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