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Plasma Cell-Rich Lymphoid Neoplasm in an Endocervical Polyp of the Uterine Cervix in a Perimenopausal 52-Year-Old Woman.
HCA Healthc J Med
February 2025
St David's North Austin Medical Center, Austin, Texas.
Background: The adaptive immune system consists of T and B lymphocytes, with some B lymphocytes further differentiating into plasma cells that secrete antibodies and make up the humoral immune system. Extramedullary plasmacytoma, mucosa-associated lymphoid tissue (MALT) lymphoma, and plasmablastic lymphoma are all plasma cell-rich lymphoid neoplasms that rarely present in the female genital tract. To date, few case reports of these malignancies arising within the uterine cervix exist.
View Article and Find Full Text PDFRectal Endometriosis-Associated Adenocarcinoma: A Rare Entity Demanding Clinical Vigilance.
Cureus
February 2025
Department of Digestive Disease, Xiamen Chang Gung Hospital, Hua Qiao University, Fujian, CHN.
Endometriosis may become malignant, and its diagnosis is challenging, especially in rare extra-ovarian sites like the rectum. Here, we describe the case of a 42-year-old woman who presented with intermittent left lower abdominal discomfort for six months. A colonoscopy revealed a 1.
View Article and Find Full Text PDF[Is there a place for prophylactic fimbriectomy followed by delayed ovariectomy?].
Bull Cancer
March 2025
Département d'oncologie chirurgicale, centre Oscar-Lambret, 3, avenue Frédéric-Combemale, 5900 Lille, France. Electronic address:
Risk reducing salpingo-oophorectomy has long been the gold standard for preventing the development of tubo-ovarian cancers in high-risk population such as BRCA1/2 mutation carriers. Although a clear survival benefit has been demonstrated of these prophylactic procedures, important side effect from the associated surgical menopause have been described. Given that recent evidence suggests that most high-grade serous carcinomas (HGSC), the majority of all ovarian carcinomas, and especially for patients with a genetic predisposition originate in the fallopian tube, where also precursor lesions such as STIC can be found, an alternative risk reduction strategy has emerged, the prophylactic fimbriectomy with delayed oophorectomy.
View Article and Find Full Text PDF[Risk-reducing bilateral salpingo-oophorectomy: For whom, how and what results?].
Bull Cancer
March 2025
Service de chirurgie et cancérologie gynécologique et mammaire, hôpital La Pitié- Salpêtrière, AP-HP, Paris, France; Centre de Recherche Saint-Antoine (CRSA), INSERM UMR_S_938, Cancer Biology and Therapeutics, Sorbonne University, 75012 Paris, France; Inserm UMR-S 938, biologie et thérapeutiques du cancer, centre de recherche Saint-Antoine (CRSA), Sorbonne Université, Paris, France.
Currently, the main means of diagnosing ovarian cancer at an early stage involve risk prediction, prevention and screening in patients identified as being at genetic risk. Our aim is to identify patients who may benefit from bilateral salpingo-oophorectomy for risk reduction purposes, as well as the modalities for its realization. We list the genes associated with ovarian cancer predisposition, their frequency in the general population, the risk of patients carrying these genes developing ovarian cancer, and the risk-reducing surgical procedures associated with each gene.
View Article and Find Full Text PDFGynecologic Cancer Screening and Prevention: State of the Science and Practice.
Curr Treat Options Oncol
February 2025
Division of Gynecologic Oncology, Department of Women's Health, University of Texas at Austin Dell Medical School, Health Discovery Building, 1601 N. Trinity Street, Austin, TX, USA.
Gynecological cancers, including cervical, endometrial, ovarian, and vulvovaginal cancer, have increasing incidence and mortality globally over the last three decades. In that time, there have been advances in medical therapies and paradigm shifts in surgical treatment which have resulted in a greater quality of life for patients. Clinicians have also refocused efforts to preventing gynecologic cancer.
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