Potent bioactive metabolites from .

Seven known (-) and one new compound () were isolated and identified from the stem of . The species has been recognised as a new source for six of the known metabolites (, , , , , and ). Based on detailed spectroscopic analyses, these compounds were identified as scopoletin (), 8-ketosetosterol (), (+)-cycloolivil (), (+)-africanal (), isovanilic acid (), hydroxytyrosol acetate (), vanillic acid (), and cycloolivil A (). The crude extracts and purified compounds were analysed for their Leishmanicidal, anti-glycation, anti-cancer, and anti-inflammatory activities. n-Hexane fraction was found to be the most active (among all the fractions), against Leishmania parasites, exhibiting 97.85% inhibition at 15 g/mL. However, none of the extracts showed any significant anti-glycation or anti-cancer potential, all the fractions, except the aqueous layer, displayed moderate to low anti-inflammatory activity. Compound was found to have strong anti-inflammatory activity, exhibiting 96.7% stimulation at 25 g/mL.