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Discovering potential ERK1 inhibitors from natural products for therapeutic targeting of Alzheimer's disease.
J Alzheimers Dis
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Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Background: Extracellular signal-regulated kinase 1 (ERK1) belongs to mitogen-activated protein kinases, which are essential for memory formation, cognitive function, and synaptic plasticity. During Alzheimer's disease (AD), ERK1 phosphorylates tau at 15 phosphorylation sites, leading to the formation of neurofibrillary tangles. The overactivation of ERK1 in microglia promotes the release of pro-inflammatory cytokines, which results in neuroinflammation.
View Article and Find Full Text PDFAdvances in Photonic and Plasmonic Nanomaterials.
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Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Nanomaterials and nanostructures with different morphologies or geometrical shapes that exploit plasmons, and particularly surface plasmon polaritons, are useful for a wide range device fabrication-related applications [...
View Article and Find Full Text PDFTopic Editorial on Photonic and Optoelectronic Devices and Systems.
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Institute of Microelectronics and Optoelectronics, Warsaw University of Technology, Koszykowa 75, 00-662 Warsaw, Poland.
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View Article and Find Full Text PDFCalorimetric measurement of energy and nutrient stimulation of microorganisms from the continental deep subsurface.
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Department of Earth Sciences, University of Southern California, Los Angeles, CA, United States.
Microbial activity in the deep continental subsurface is difficult to measure due to low cell densities, low energy fluxes, cryptic elemental cycles and enigmatic metabolisms. Nonetheless, direct access to rare sample sites and sensitive laboratory measurements can be used to better understand the variables that govern microbial life underground. In this study, we sampled fluids from six boreholes at depths ranging from 244 m to 1,478 m below ground at the Sanford Underground Research Facility (SURF), a former goldmine in South Dakota, United States.
View Article and Find Full Text PDFThe future of cell-free synthetic biology.
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Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Cell-free synthetic biology aims at the targeted replication, design, and modification of life processes in open systems by breaking free of constraints such as cell membrane barriers and living cell growth. The beginnings of this systematized technology, which took place in the last century, were used to explore the secrets of life. Currently, with its easy integration with other technologies or disciplines, cell-free synthetic biology is developing into a powerful and effective means of understanding, exploiting, and extending the structure and function of natural living systems.
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