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Targeting Metabolic Adaptation of Colorectal Cancer with Vanadium-Doped Nanosystem to Enhance Chemotherapy and Immunotherapy.
Adv Sci (Weinh)
December 2024
Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
The anti-tumor efficacy of current pharmacotherapy is severely hampered due to the adaptive evolution of tumors, urgently needing effective therapeutic strategies capable of breaking such adaptability. Metabolic reprogramming, as an adaptive survival mechanism, is closely related to therapy resistance of tumors. Colorectal cancer (CRC) cells exhibit a high energy dependency that is sustained by an adaptive metabolic conversion between glucose and glutamine, helping tumor cells to withstand nutrient-deficient microenvironments and various treatments.
View Article and Find Full Text PDFInsights and progress on the biosynthesis, metabolism, and physiological functions of gamma-aminobutyric acid (GABA): a review.
PeerJ
December 2024
Department of Medicine, Qingdao Binhai University, Qingdao, Shandong, China.
GABA (γ-aminobutyric acid) is a non-protein amino acid that occurs naturally in the human brain, animals, plants and microorganisms. It is primarily produced by the irreversible action of glutamic acid decarboxylase (GAD) on the α-decarboxylation of L-glutamic acid. As a major neurotransmitter in the brain, GABA plays a crucial role in behavior, cognition, and the body's stress response.
View Article and Find Full Text PDFWho's Prone to Breaking the Rules?-Predictors of Challenging Patient Behavior in Forensic Addiction Treatment.
Int J Offender Ther Comp Criminol
December 2024
LVR-Institut für Versorgungsforschung, c/o LVR-Klinik Köln, Germany.
Many patients in substance use disorder treatment exhibit behavior that is challenging for therapy. In Germany, offenders with addiction problems may be sentenced to treatment in forensic psychiatric institutions (Sect. 64 of the German Criminal Code).
View Article and Find Full Text PDFMathematical basis and toolchain for hierarchical optimization of biochemical networks.
PLoS Comput Biol
December 2024
National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore, India.
Biological signalling systems are complex, and efforts to build mechanistic models must confront a huge parameter space, indirect and sparse data, and frequently encounter multiscale and multiphysics phenomena. We present HOSS, a framework for Hierarchical Optimization of Systems Simulations, to address such problems. HOSS operates by breaking down extensive systems models into individual pathway blocks organized in a nested hierarchy.
View Article and Find Full Text PDFChiral spin-liquid-like state in pyrochlore iridate thin films.
Nat Commun
November 2024
Department of Physics and Astronomy, Rutgers University, Piscataway, NJ, USA.
Article Synopsis
- Pyrochlore iridates are notable for studying complex phenomena due to their strong spin-orbit coupling, electronic interactions, and geometrically frustrated lattice structures.
- In thin films of (111) YIrO with thicknesses ≤30 nm, researchers found a unique quantum disordered state at temperatures as low as 5 K, which was characterized by dispersionless magnetic excitations.
- Below approximately 125 K, an anomalous Hall effect suggests the existence of chiral spin configurations, attributed to magnetic frustration in the lower-dimensional structure that leads to spin-liquid behavior without long-range order.
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