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Quantitative imaging of loop extruders rebuilding interphase genome architecture after mitosis.
J Cell Biol
March 2025
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL) , Heidelberg, Germany.
How cells establish the interphase genome organization after mitosis is incompletely understood. Using quantitative and super-resolution microscopy, we show that the transition from a Condensin to a Cohesin-based genome organization occurs dynamically over 2 h. While a significant fraction of Condensins remains chromatin-bound until early G1, Cohesin-STAG1 and its boundary factor CTCF are rapidly imported into daughter nuclei in telophase, immediately bind chromosomes as individual complexes, and are sufficient to build the first interphase TAD structures.
View Article and Find Full Text PDFUncertainty Quantification and Sensitivity Analysis for Non-invasive Model-Based Instantaneous Wave-Free Ratio Prediction.
Int J Numer Method Biomed Eng
January 2025
Department of Mathematics, University of Trento, Trento, Italy.
The main objectives of this work are to validate a 1D-0D unsteady solver with a distributed stenosis model for the patient-specific estimation of resting haemodynamic indices and to assess the sensitivity of instantaneous wave-free ratio (iFR) predictions to uncertainties in input parameters. We considered 52 patients with stable coronary artery disease, for which 81 invasive iFR measurements were available. We validated the performance of our solver compared to 3D steady-state and transient results and invasive measurements.
View Article and Find Full Text PDFDurability of Wood-Cement Composites with Modified Composition by Limestone and Stabilised Spruce Chips.
Materials (Basel)
December 2024
Institute of Technology of Building Materials and Components, Faculty of Civil Engineering, Brno University of Technology, 602 00 Brno, Czech Republic.
Limestone (LS) and stabilised secondary spruce chips (SCs) utilisation in wood-cement composites is still an unexplored area. Therefore, the main objective of the research presented here is the assessment of the long-term behaviour of cement-bonded particleboards (CBPs) modified by LS and SCs. Cement (CE) was replaced by 10% of LS, and spruce chips by 7% of SCs.
View Article and Find Full Text PDFEndoscopic Ultrasound-Guided Pancreatic Tissue Sampling: Lesion Assessment, Needles, and Techniques.
Medicina (Kaunas)
December 2024
Department of Medicine, Diagnostic and Interventional Endoscopy of the Pancreas, The Pancreas Institute, University Hospital of Verona, 37134 Verona, Italy.
Endoscopic ultrasound (EUS)-guided tissue sampling includes the techniques of fine needle aspiration (FNA) and fine needle biopsy (FNB), and both procedures have revolutionized specimen collection from the gastrointestinal tract, especially from remote/inaccessible organs. EUS-FNB has replaced FNA as the procedure of choice for tissue acquisition in solid pancreatic lesions (SPLs) across various society guidelines. FNB specimens provide a larger histological tissue core (preserving tissue architecture) with fewer needle passes, and this is extremely relevant in today's era of precision and personalized molecular medicine.
View Article and Find Full Text PDFTotal wrist arthroplasty: recent advances and current recommendations.
J Hand Surg Eur Vol
January 2025
Orthopaedic Department, Martina Hansens Hospital, Norway.
The latest generation of wrist arthroplasties provides good clinical function and pain relief with an acceptable revision/reoperation rate. The procedure is complex and technically demanding, both for the surgeon and the patient. The available implants (with the exception of one) have not been developed or refined in the last decade, which reduces the versatility and ability to adapt to specific patient anatomy, to manage implant/treatment problems and to perform successful revisions.
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