AI Article Synopsis
- Two elderly patients with multiple health issues presented with severe itchy blisters (bullae) after taking linagliptin for diabetes over six weeks.
- Despite linagliptin's benefits for controlling blood sugar and its safety profile, these cases indicate a significant risk of developing bullous pemphigoid, a serious skin condition.
- The combination of bullous pemphigoid and existing heart valve issues led to increased chances of severe infections like endocarditis, prompting a recommendation for cautious prescribing of linagliptin.
Article Abstract
We describe two patients, in their 70s, each presenting to the emergency department, with 6-week histories of progressively developing pruritic bullae. Both individuals had multiple comorbidities, including type 2 diabetes-for which they took linagliptin, chronic kidney disease, hypertension and prosthetic heart valves. Owing to systemic illness and endocarditis secondary to superadded bacterial infections, they both required intensive treatment and prolonged hospital admissions.Despite the beneficial effect of linagliptin on glycaemic control and its reported cardiovascular and renal safety profiles, we add our cases as evidence of the significant risk of developing bullous pemphigoid while taking this medication. Secondary infection of bullous pemphigoid increased the risk of developing endocarditis, particularly among individuals with a medical history of valve replacement surgery. Considering this, we advocate caution when prescribing this medication.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10868317 | PMC |
| http://dx.doi.org/10.1136/bcr-2023-255358 | DOI Listing |
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