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Alzheimers Dement
December 2024
The Chinese University of Hong Kong, Hong Kong, Hong Kong.
Background: Emerging evidence strongly suggests that terminally differentiated neurons in the brain have the potential to undergo a cell cycle-like process during neuronal aging and in the presence of certain diseases. However, due to their infrequent occurrence and unpredictable distribution within the brain, the molecular characteristics and specific variations associated with these cells in different diseases are still not well understood.
Method: By taking advantage of the wealth of human brain single-nucleus RNA sequencing (snRNA-seq) datasets available in public repositories, we developed an analytical pipeline that facilitates the identification and characterization of cell cycle gene re-expressing neurons to address these questions.
Unusual outcome of treatment of thymoma with immunotherapy: case report.
Mediastinum
November 2024
Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Background: Thymoma is a rare mediastinal neoplasm originating from thymic epithelial cells, often associated with paraneoplastic syndromes. These syndromes can manifest as a range of autoimmune disorders, including myasthenia gravis, pure red cell aplasia, and aplastic anemia. Clinical trials involving the use of immune checkpoint inhibitors (ICIs) in thymoma have been complicated by a high incidence of immune-related adverse effects (irAEs).
View Article and Find Full Text PDFAn early precursor CD8 T cell that adapts to acute or chronic viral infection.
Nature
January 2025
Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
This study examines the origin and differentiation of stem-like CD8+ T cells that are essential for sustained T cell immunity in chronic viral infections and cancer and also play a key role in PD-1 directed immunotherapy. These PD-1+ TCF-1+ TOX+ stem-like CD8+ T cells, also referred to as precursors of exhausted T cells, have a distinct program that allows them to adapt to chronic antigen stimulation. Using the mouse model of chronic LCMV infection we found that virus specific stem-like CD8+ T cells are generated early (day 5) during chronic infection suggesting that this crucial fate commitment occurs irrespective of infection outcome.
View Article and Find Full Text PDFThe Gene Related to the Family Genes: An Evolutionary View on Origin and Function.
Int J Mol Sci
December 2024
Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 26 Vavilov Street, 119334 Moscow, Russia.
has two paralogs, and , related to the evolutionarily conserved family genes. In mammals, the family consists of , encoding transcription co-factors involved in the regulation of development and cell fate determination. The function of and in remains unclear.
View Article and Find Full Text PDFOn the Tracks to "Smart" Single-Atom Catalysts.
J Am Chem Soc
January 2025
Department of Chemical and Pharmaceutical Sciences, Center for Energy, Environment and Transport Giacomo Ciamiciam, INSTM Trieste Research Unit and ICCOM-CNR Trieste Research Unit, University of Trieste, Via L. Giorgieri 134127Trieste, Italy.
Despite their enormous impact in modern heterogeneous catalysis, single-atom catalysts (SACs) continue to puzzle the catalysis community, which often struggles to draw correct conclusions in SAC-catalyzed experiments. In many cases, the reasons for such an uncertainty originate from the lack of knowledge of the exact single-atom evolution under operative conditions and the fundamental factors controlling the fate of the single atom in relation to the catalytic mechanism. This has led to confusion also about correct definition and terminology, where the coined term reflects the difficulty in defining the true active species as well as in obtaining long-range ordered homogeneous supports [Chi, S.
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