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The Glycopeptide PV-PS A1 Immunogen Elicits Both CD4+ and CD8+ Responses.
Vaccines (Basel)
December 2024
Department of Chemistry and Biochemistry and School of Green Chemistry and Engineering, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606, USA.
Background/objectives: The MHCII-dependent, CD4+ T-cell zwitterionic polysaccharide PS A1 has been investigated as a promising carrier for vaccine development because it can induce an MHCII-dependent CD4+ response towards a variety of tumor-associated carbohydrate antigens (TACAs). However, PS A1 cannot elicit cytotoxic T lymphocytes through MHCI, which may or may not hamper its potential clinical use in cancer, infectious and viral vaccine development. This paper addresses PS A1 MHCI independence through the introduction of an MHCI epitope, the poliovirus (PV) peptide, to establish an MHCI- and MHCII-dependent vaccine.
View Article and Find Full Text PDFAdvances in Encapsulating Marine Bioactive Compounds Using Nanostructured Lipid Carriers (NLCs) and Solid Lipid Nanoparticles (SLNs) for Health Applications.
Pharmaceutics
November 2024
UCIBIO (Applied Molecular Biosciences Unit), Laboratory of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.
As life expectancy rises and modern lifestyles improve, there is an increasing focus on health, disease prevention, and enhancing physical appearance. Consumers are more aware of the benefits of natural ingredients in healthcare products while also being mindful of sustainability challenges. Consequently, marine bioactive compounds have gained popularity as ingredients in cosmetics and food supplements due to their diverse beneficial properties.
View Article and Find Full Text PDFEnvironmentally Sustainable and Green Polymeric Method for Chitosan (CH) Film Synthesis Using Natural Acids and Impact of Zinc Ferrite Nanoparticles (NPs) on Water Solubility (WS) and Physical Properties.
Polymers (Basel)
December 2024
School of Engineering and Sciences, Tecnologico de Monterrey, Atizapan de Zaragoza C.P. 52926, Estado de Mexico, Mexico.
Currently, there is a rush to develop green polymeric films such as biodegradable chitosan (CH) films to control and prevent plastic pollution from degrading the environment. This study reports a novel and sustainable green approach to the development of CH films using lemon juice (LJ) and lemon peel extract (LPE), the latter to dilute the LJ. The LPE was also utilized for the synthesis of ZnFeO nanoparticles (NPs), adding to this work's novelty.
View Article and Find Full Text PDFThe Impact of Nickel-Zinc Ferrite Nanoparticles on the Mechanical and Barrier Properties of Green-Synthesized Chitosan Films Produced Using Natural Juices.
Polymers (Basel)
December 2024
Tecnologico de Monterrey, School of Engineering and Sciences, Atizapan de Zaragoza C.P. 52926, Estado de Mexico, Mexico.
A trend has been established concerning the research and development of various green and biodegradable plastics for multi-purpose applications, aiming to replace petroleum-based plastics. Herein, we report the synthesis of chitosan (CH) films using lemon juice; these were reinforced with NiZnFeO nanoparticles (NiZnFeO NPs) to obtain improved mechanical and barrier properties, facilitating their future application as sustainable, corrosion-resistant coatings for medical instruments. The synthesized NiZnFeO NPs had a crystallite size of ~29 nm.
View Article and Find Full Text PDFExploring Microelement Fertilization and Visible-Near-Infrared Spectroscopy for Enhanced Productivity in and Aquaponic Systems.
Plants (Basel)
December 2024
Faculty of Agriculture, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria.
This study explores the effects of varying exposure times of microelement fertilization on hydrochemical parameters, plant growth, and nutrient content in an aquaponic system cultivating L. (pepper) with ( L.).
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