The first catalytic enantioselective [5+1] cycloaddition reactions of -cyclic azomethine imines with isocyanides are reported herein. The method displays a broad substrate scope and atom-economy. A series of chiral tetrahydroisoquinoline containing indole skeletons were obtained in up to 90% yield with 95% ee under mild reaction conditions. A possible catalytic model was also proposed.
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http://dx.doi.org/10.1039/d3cc05890e | DOI Listing |
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