Key Clinical Message: Pleomorphic adenoma is a common epithelial tumor but is unusual to involve the nasolacrimal duct and lacrimal sac. Current reported cases are sparse but may be helpful for delineating patterns of malignant transformation in the future.
Abstract: This is a report of a 66-year-old patient with a pleomorphic adenoma involving the nasolacrimal duct and lacrimal sac, which is an unusual location for these tumors. To our knowledge, there are scarce publications in the current literature of similar cases.
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http://dx.doi.org/10.1002/ccr3.8504 | DOI Listing |
Case Rep Dent
January 2025
Department of Conservative Dentistry and Endodontics, College of Dental Surgery, B.P. Koirala Institute of Health Sciences, Dharan, Nepal.
Pleomorphic adenoma (PA), the most common salivary gland tumor, presents unique challenges due to its diverse clinicopathologic features. The objective of this case series is to highlight the implication of detailed histopathological examination to guide appropriate diagnosis. This study reviews 10 cases of PA diagnosed at B.
View Article and Find Full Text PDFCarcinoma ex pleomorphic adenomas are rare malignant tumors of the salivary glands, primarily seen in older adults. They originate from benign pleomorphic adenomas, are aggressive, and have poorer prognosis. This case documents an unusual presentation of a massive carcinoma ex pleomorphic adenoma.
View Article and Find Full Text PDFVirchows Arch
January 2025
Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Pleomorphic adenoma (PA), the most prevalent salivary gland tumor, exhibits a diverse histological spectrum characterized by epithelial, myoepithelial, and mesenchymal patterns, and secretory products. However, a subset of PAs presents microscopic features suggestive of malignancy, leading to challenging and potentially significant diagnostic pitfalls. A comprehensive retrospective analysis was conducted on the Salivary Gland Tumor Registry, compiled by the authors.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Department of Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Aurora kinase A (AurkA) plays a vital role in mitosis and is therefore critical in tumors development and progression. There are a few studies on AurkA expression in salivary gland tumors. The aim of the present study was to evaluate the expression pattern of AurkA in the most common benign and malignant salivary gland tumors by immunohistochemistry.
View Article and Find Full Text PDFTransl Cancer Res
December 2024
Department of Stomatology, The First Hospital of Lanzhou University, Lanzhou, China.
Background: The rising incidence of parotid gland tumors, with a focus on pleomorphic adenomas (PMA) and Warthin tumors (WT), necessitates accurate preoperative distinction due to their treatment variability and PMA's malignant potential. Traditional imaging, while valuable, has limited accuracy. This study employs multi-slice computed tomography (MSCT) radiomics coupled with serum alpha-L-fucosidase (AFU) levels to develop a diagnostic model aimed at elevating clinical discernment and precision therapy delivery.
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