AI Article Synopsis
- - A novel indole alkaloid named vincazalidine A was discovered from the plant Catharanthus roseus, featuring a unique structure that combines elements of aspidosperma and iboga types with a complex ring system.
- - The chemical structure and stereochemistry of vincazalidine A were determined using various spectroscopic techniques and statistical analysis.
- - Vincazalidine A was found to cause G2 phase cell cycle arrest and trigger apoptosis in A549 human lung cancer cells, suggesting its potential as an anti-cancer agent.
Article Abstract
A new dimeric indole alkaloid, vincazalidine A consisting of an aspidosperma type and a modified iboga type with 1-azatricyclo ring system consisting of one azepane and two piperidine rings coupled with an oxazolidine ring was isolated from Catharanthus roseus, and the structure including absolute stereochemistry was elucidated on the basis of spectroscopic data as well as DP4 statistical analysis. Vincazalidine A induced G2 arrest and subsequent apoptosis in human lung carcinoma cell line, A549 cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11418-023-01775-x | DOI Listing |
Publication Analysis
Top Keywords
catharanthus roseus
8
vincazalidine unique
4
unique bisindole
4
bisindole alkaloid
4
alkaloid catharanthus
4
roseus dimeric
4
dimeric indole
4
indole alkaloid
4
alkaloid vincazalidine
4
vincazalidine consisting
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!