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A network analysis of postpartum depression and mother-to-infant bonding shows common and unique symptom-level connections across three postpartum periods.
Commun Psychol
January 2025
Cancer Control Center, Osaka International Cancer Institute, Osaka, Japan.
Postpartum depression and mother-to-infant bonding difficulties (MIBD), two issues crucial to maternal and infant mental health, often coexist and affect each other. Our study aims to dissect their complex relationship through a graphical LASSO network analysis of individual symptoms in 5594 Japanese postpartum women, whose geographical distribution was nationally representative. We identified 'fear', 'enjoyment', 'overwhelm', and 'insomnia' as common bridge symptoms linking postpartum depression and MIBD across three distinct postpartum periods.
View Article and Find Full Text PDFUnveiling the intricacies: Insight into gastroesophageal reflux disease.
World J Gastroenterol
January 2025
Department of Physiology, Faculty of Medicine, University of Kelaniya, Ragama 11010, Western Province, Sri Lanka.
Gastroesophageal reflux disease (GERD) poses a substantial global health challenge, with prevalence rates exhibiting geographical variation. Despite its widespread recognition, the exact prevalence and associated risk factors remain elusive. This article comprehensively analyzed the global burden of GERD, shedding light on its risk factors, underlying pathophysiological mechanisms, current diagnostic modalities, evolving management strategies tailored to diverse patient profiles, and complex determinants contributing to treatment failures.
View Article and Find Full Text PDFGenome-wide association mapping in safflower (Carthamus tinctorius L.) for genetic dissection of drought tolerance using DArTseq markers.
Sci Rep
December 2024
Department of Agronomy and Plant Breeding, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.
Understanding the genetic basis of drought tolerance in safflower (Carthamus tinctorius L.) is essential for developing resilient varieties. In this study, we performed a genome-wide association study (GWAS) using DArTseq markers to identify marker-trait associations (MTAs) linked to drought tolerance across 90 globally diverse safflower genotypes.
View Article and Find Full Text PDFInsight into metabolic dysregulation of polycystic ovary syndrome utilizing metabolomic signatures: a narrative review.
Crit Rev Clin Lab Sci
December 2024
Department of Molecular Endocrinology, National Institute for Research in Reproductive and Child Health, Indian Council of Medical Research, Mumbai, India.
Polycystic ovary syndrome (PCOS) is a complex multifactorial endocrinopathy affecting reproductive aged women globally, whose presentation is strongly influenced by genetic makeup, ethnic, and geographic diversity leaving these affected women substantially predisposed to reproductive and metabolic perturbations. Sophisticated techniques spanning genomics, proteomics, epigenomics, and transcriptomics have been harnessed to comprehensively understand the enigmatic pathophysiology of PCOS, however, conclusive markers for PCOS are still lacking today. Metabolomics represents a paradigm shift in biotechnological advances enabling the simultaneous identification and quantification of metabolites and the use of this approach has added yet another dimension to help unravel the strong metabolic component of PCOS.
View Article and Find Full Text PDFGPA1 is a determinant of leaf width and fruit size in tomato.
Plant Sci
November 2024
Academy of Agricultural and Forestry Sciences, Qinghai University, Laboratory for Research and Utilization of Qinghai Tibet Plateau Germplasm Resources, Xining 810016, China.
The identification and dissection of the genetic foundations underlying natural variations in crop species are critical for understanding their phenotypic diversity and for subsequent application in selective breeding. In this research, we identify a natural polymorphism in the promoter region of the G protein α subunit 1 (GPA1) gene, which is associated with the width of the tomato leaves. This may be an evolutionary consequence resulting from the domestication processes aimed at increasing fruit size.
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