Potential Gastric Cancer Immunotherapy: Stimulating the Immune System with pIRES2-DsRed-Express- DNA Vaccines.

Most gastric cancers (GC) are thought to be caused by () infections. However, there is mounting evidence that GC patients with positive status have improved prognoses. The -induced cellular immune reaction may inhibit cancer. In this study, BALB/c mice were immunized using recombinant plasmids that encode the gene of . Purified functional splenic CD3 T lymphocytes are used to study the anticancer effects and . The immunological state of GC patients with ongoing infection is mimicked by the DNA vaccines, which cause a change in the reaction from Th1 to Th2. Human GC cells grow more slowly when stimulated CD3 T lymphocytes are used as adoptive infusions because they reduce GC xenograft development . The more excellent ratios of infiltrating CD8/CD4 T cells, the decreased invasion of regulatory FOXP3 Treg lymphocytes, and the increased apoptosis brought on by Caspase9/Caspase-3 overexpression and Survivin downregulation may all contribute to the consequences. Our findings suggest that in people with advanced GC, pIRES2-DsRed-Express- DNA vaccines may have immunotherapeutic utility.