AI Article Synopsis
- This meta-analysis investigates the effects of varicocoelectomy on sperm morphology specifically in patients with isolated teratozoospermia, a rare condition affecting sperm shape and quality.
- Out of 1,013 studies screened, five met the inclusion criteria, involving 348 male patients, and found that varicocoelectomy significantly improved sperm morphology but showed no notable change in sperm concentration.
- Additionally, the analysis indicated a high pregnancy rate among patients post-surgery, though potential publication bias was identified in the findings.
Article Abstract
Background: Clinical palpable varicocoeles in conjunction with isolated teratozoospermia are rarely observed. Therefore, the effects of varicocoelectomy on sperm morphology are not clear. The aim of this meta-analysis is to compile studies that assess the effectiveness of varicocoelectomy in isolated teratozoospermia to reach a more consistent and reliable conclusion.
Material-methods: The present meta-analysis was registered to PROSPERO (CRD42023467933). We utilized the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline to report the outcomes. Articles published before 1 October 2023 were included in the study. The search terms used were teratozoospermia, isolated teratozoospermia, varicocoelectomy for isolated teratozoospermia, and semen analysis after varicocoelectomy in isolated teratozoospermia.
Results: We identified 1,013 studies in full publications or abstracts using the methodology and the search terms. Five studies were included for systematic review, while four were included for meta-analysis. The five studies (10-14) included 348 patients aged 18-44 years. The pooled analysis revealed a significant improvement in sperm morphology in isolated teratozoospermia patients undergoing varicocoelectomy (Q = 199.42, p < 0.0001; I = 98.49%). The pooled analysis revealed no significant improvement in sperm concentration in isolated teratozoospermia patients undergoing varicocoelectomy (Q = 5.69, p = 0.058; I = 64.85%). Three of the examined studies provided information regarding pregnancy rate and it was high in all studies. According to the Newcastle-Ottowa scale (NOS) assessment, the total quality score of all studies was 7. The funnel plot test demonstrated a visible asymmetry, and Begg and Mazumdar's rank correlation test confirmed the publication bias (p = 0.04).
Discussion: Varicocoelectomy can be an effective and reliable treatment option in patients with isolated morphology abnormalities and clinically palpable varicocoele.
Conclusion: This meta-analysis reported that varicocoelectomy may increase pregnancy rates by improving semen parameters in infertile men with isolated teratozoospermia, although this conclusion requires further evidence.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/andr.13602 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sperm morphology value in assisted reproduction: dismantling an enigma and key takeaways for the busy clinician.
Ther Adv Reprod Health
December 2024
Global Andrology Forum, Moreland Hills, OH, USA.
The ideal morphology of the sperm cell was initially described based on the characteristics of sperm able to migrate through the endocervical canal assuming these had the best fertilization potential. Sperm morphology assessment has moved over the years toward stricter criteria based on the findings from studies that underline its value in successful reproductive outcomes. While treatment options are clear for some conditions related to abnormal sperm morphology, the value of sperm morphology in assisted reproduction requires further investigation.
View Article and Find Full Text PDFRole of sperm morphological parameters in the selection of fertilization methods.
Rev Int Androl
September 2024
Department of Reproductive Medicine, The Maternal and Child Health Hospital of Changde City, 415000 Changde, Hunan, China.
Article Synopsis
- The study investigates the effectiveness of IVF versus ICSI for couples dealing with isolated teratozoospermia, a sperm condition affecting fertility.
- Conducted from January 2018 to December 2022, the research involved 433 couples, with 81 patients specifically diagnosed with isolated teratozoospermia.
- Results indicated that both moderate and severe teratozoospermia patients had comparable success rates with IVF, and R-ICSI was only used when necessary, suggesting IVF is a viable treatment option for these cases.
Contemporary challenges and advanced technologies in the management of subfertile men with varicocele.
Rev Int Androl
September 2024
Surgical Department, Republican Specialized Scientific-Practical Medical Center of Urology, 100109 Tashkent, Uzbekistan.
Article Synopsis
- - Varicocele is closely linked to male fertility but has many unresolved issues that require urgent research, particularly regarding diagnosis and treatment protocols.
- - The lack of clear semen parameter reference values in the WHO manual makes it difficult to differentiate between normal and abnormal cases, complicating clinical decisions like whether to perform varicocelectomy.
- - There is a pressing need for large-scale clinical trials to clarify the effects of varicocele on fertility and to establish evidence-based management strategies, particularly for cases of isolated teratozoospermia and subfertility after surgery.
Sperm morphology by strict criteria does not predict clinical pregnancy rate following intra-uterine insemination.
Arab J Urol
March 2024
Department of Infertility, Fakih IVF Fertility Center, Dubai, United Arab Emirates.
Objective: To determine the impact of abnormal sperm morphology of the pre-washed semen sample on the day of intrauterine insemination (IUI) on clinical pregnancy rates (CPR).
Design: Cross sectional retrospective chart review.
Setting: Academic fertility center.
The challenges in diagnosing isolated epididymal tuberculosis (TB) in an adolescent male: a case report.
BMC Urol
March 2024
Division of Respirology, Department of Child Health, Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin General Hospital, Pasteur Street No. 38, Sukajadi, Bandung, West Java, 40161, Indonesia.
Background: Genitourinary tuberculosis (GUTB) is a common form of extrapulmonary TB (EPTB) in children. An example of GUTB is epididymal TB, which usually presents unspecific chronic clinical manifestations. Definitive diagnosis can be conducted based on bacteriologic confirmation and histopathologic results, but this is challenging due to the paucibacillary nature of EPTB.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!