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A microenvironment-adaptive GelMA-ODex@RRHD hydrogel for responsive release of HS in promoted chronic diabetic wound repair.
Regen Biomater
November 2024
Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma and Chemical Poisoning, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Chronic diabetic wounds present significant treatment challenges due to their complex microenvironment, often leading to suboptimal healing outcomes. Hydrogen sulfide (HS), a crucial gaseous signaling molecule, has shown great potential in modulating inflammation, oxidative stress and extracellular matrix remodeling, which are essential for effective wound healing. However, conventional HS delivery systems lack the adaptability required to meet the dynamic demands of different healing stages, thereby limiting their therapeutic efficacy.
View Article and Find Full Text PDFDCA-YOLOv8: A Novel Framework Combined with AICI Loss Function for Coronary Artery Stenosis Detection.
Sensors (Basel)
December 2024
School of Information Engineering and Automation, Kunming University of Science and Technology, Kunming 650500, China.
Coronary artery stenosis detection remains a challenging task due to the complex vascular structure, poor quality of imaging pictures, poor vessel contouring caused by breathing artifacts and stenotic lesions that often appear in a small region of the image. In order to improve the accuracy and efficiency of detection, a new deep-learning technique based on a coronary artery stenosis detection framework (DCA-YOLOv8) is proposed in this paper. The framework consists of a histogram equalization and canny edge detection preprocessing (HEC) enhancement module, a double coordinate attention (DCA) feature extraction module and an output module that combines a newly designed loss function, named adaptive inner-CIoU (AICI).
View Article and Find Full Text PDFBackground: There is continuous demand for safe, effective cosmetic ingredients to treat the signs of aging skin, including fine lines, wrinkles, brown spots, discoloration, laxity, and sagging. While there are a plethora of cosmeceutical peptides, few combine anti-aging and anti-inflammatory benefits with small size.
Methods: Preclinical and clinical studies evaluated the anti-inflammatory properties, anti-aging benefits, and tolerability of acetyl dipeptide-31 amide (AP31), a novel, small, anti-aging micropeptide, to understand its impact as a multifaceted, cosmetic, anti-aging, and anti-inflammaging ingredient.
Local corner smoothing based on deep learning for CNC machine tools.
Sci Rep
January 2025
College of Intelligent systems Science and Engineering, Harbin Engineering University, Harbin, 150006, China.
Most of toolpaths for machining is composed of series of short linear segments (G01 command), which limits the feedrate and machining quality. To generate a smooth machining path, a new optimization strategy is proposed to optimize the toolpath at the curvature level. First, the three essential components of optimization are introduced, and the local corner smoothness is converted into an optimization problem.
View Article and Find Full Text PDFThis study examines the efficacy of jaw exercising products for facial contouring. The two individuals used a commercially available jaw exerciser for approximately three months, following the provided instructions. Neither case reported noticeable changes in jaw appearance based on subjective measurements.
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