Background: Recently, many studies have reported that there may be association between positive right-to-left shunt (RLS) and migraine, especially Migraine with aura (MA) patients. However, these researches are mostly limited in Western country. And the latest study describing the prevalence of RLS in Chinese patients with migraine was conducted five years ago. It indicated the significant higher rate of positive RLS in MA patients than migraine without aura(MWOA) group. However, no consistent results were observed according to our daily work.
Objective: To investigate the prevalence and grade of RLS in migraine patients with and without aura and to evaluate the potential association between positive RLS and migraine with aura.
Methods: A total of 91 migraine patients were involved, including 57 MWOA patients and 34 MA patients. MWOA and MA were diagnosed according to the International Classification of Headache Disorders, 3rd edition (beta version) (ICHD-3). Contrast transcranial Doppler ultra-sound (cTCD) was used to assess the prevalence of positive RLS, the associations between RLS and presence of aura.
Results: The overall prevalence of RLS in migraine patients was 35.2%. In MA group, 44.1% (15/34) were positive for RLS overall, higher than MWOA group (29.8%,17/57). However, the differences were not significant (P = 0.167). And there were no marked differences in the prevalence of large, middle and small shunt between MA and MWOA patients.
Conclusion: Our study suggested MA patients have the slightly higher prevalence of positive RLS than MWOA patients in China. However, there were no significant differences, which was different from the previous studies. Our findings suggested the negative association between the positive RLS and migraine with aura.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clineuro.2023.108020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis.
Brain
December 2024
Neuroimmunology Research Group, Netherlands Institute for Neuroscience, 1105BA, Amsterdam, The Netherlands.
Multiple sclerosis (MS) is a highly heterogeneous disease with varying remyelination potential across individuals and between lesions. However, the molecular mechanisms underlying the potential to remyelinate remain poorly understood. In this study, we aimed to take advantage of the intrinsic heterogeneity in remyelinating capacity between MS donors and lesions to uncover known and novel pro-remyelinating molecules for MS therapies.
View Article and Find Full Text PDFThe impact of neuropsychiatric burden on Restless Legs Syndrome (RLS) disease severity.
Sleep Med
December 2024
Department of Family Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkiye. Electronic address:
Objective: In patients with Restless Legs Syndrome (RLS), neuropsychiatric comorbidities like anxiety, depression, and somatization are common, yet the precise connection between somatization and RLS severity remains unclear. This study aims to elucidate the influence of neuropsychiatric comorbidities on RLS severity, focusing particularly on the role of somatization.
Methods: This cross-sectional analytical study was conducted at a tertiary hospital.
Association between long-term exposure to air pollution and incidence of peripheral artery disease: Evidence from a longitudinal study.
Eur J Intern Med
December 2024
IRCCS Ca' Granda Maggiore Policlinico Hospital Foundation, Italy; Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy. Electronic address:
Introduction: The association between air pollution and cardiovascular diseases is well established. However, fewer studies focused on the relationship between air pollution and peripheral artery disease (PAD), notwithstanding that not only it is a predictor of CVD mortality but also that incidence is globally rising, particularly in low-middle income countries.
Objectives: The aim of this study is to estimate the association between long-term exposure to air pollutants and the incidence of PAD in the Rome Longitudinal Study (RLS) during 2011-2019.
Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions.
Circulation
January 2025
Physiology Unit, Laboratory of Malaria and Vector Research (S.D.B., A.P.R., X.Z., M.A.H., L.A.R., R.L.S., M.J., J.N.d.R., A.J.M., J.M.J., R.O.E., N.T., K.L., H.C.A.), National Institute of Allergy and Infectious Diseases, Rockville, MD.
Background: Severe malaria is associated with impaired nitric oxide (NO) synthase (NOS)-dependent vasodilation, and reversal of this deficit improves survival in murine models. Malaria might have selected for genetic polymorphisms that increase endothelial NO signaling and now contribute to heterogeneity in vascular function among humans. One protein potentially selected for is alpha globin, which, in mouse models, interacts with endothelial NOS (eNOS) to negatively regulate NO signaling.
View Article and Find Full Text PDFEchocardiography-derived regional strain for assessment of non-culprit stenosis and prediction of systolic function recovery in acute STEMI.
Int J Cardiovasc Imaging
December 2024
Amsterdam UMC, location VUmc, Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.
To compare echocardiographic regional longitudinal strain with quantitative coronary angiography and assess temporal changes in regional strain in patients with STEMI and multivessel coronary artery disease. Thirty-two patients with STEMI and multivessel coronary artery disease underwent coronary angiography with 3D quantification and baseline echocardiography. Regional longitudinal strain was measured as the average strain of three adjacent myocardial segments (RLS-3S) with the most impaired strain values.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!