Fabrication and Partial Characterization of Silver Nanoparticles From Mangrove (Avicennia marina) Leaves and Their Antibacterial Efficacy Against Oral Bacteria.

Background: Scientists are currently investigating ecologically sound and enduring techniques for nanoparticle production. Utilizing natural sources such as plant extracts provides an environmentally friendly and economically efficient method. , also referred to as the gray mangrove, is predominantly located in coastal regions. The leaves of this plant may contain bioactive metabolites that can be used to synthesize nanoparticles.

Objectives: This study aimed to synthesize silver nanoparticles (AgNPs) using leaf extract and subsequently assess their antibacterial properties against oral pathogens.

Materials And Methods: The present research involved the successful synthesis of AgNPs using an environmentally sustainable method employing the leaf extract of The reduction of Ag ions to AgNPs was confirmed using UV-visible spectroscopy. This analytical technique revealed the presence of a distinct surface plasmon resonance peak at approximately 420 nm, which is indicative of the formation of AgNPs. Fourier transform infrared spectroscopy (FTIR) operating within the frequency range of 500-3500 cm and scanning electron microscopy (SEM) morphology of the image indicated agglomeration of the nanoparticles, with distinct particles ranging from 10 to 20 nm and dense rod-shape, which was carried out from Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, India. In energy-dispersive spectroscopy (EDS), a strong signal and maximum formation percentage were received at 42.7%, assigned to the element silver.

Results: AgNPs showed significant antibacterial efficacy against both gram-positive bacteria, including and , and gram-negative bacteria, such as sp. In general, the use of leaf extract for the green synthesis of AgNPs is a viable and environmentally friendly approach for producing nanoparticles that exhibit favorable biological properties. Consequently, these nanoparticles hold considerable appeal as potential candidates for a range of biomedical applications, particularly as antibacterial agents.

Conclusion: The synthesis of AgNPs using leaf extract shows great potential in the field of creating nanomaterials that are compatible with biological systems and is promising for a wide range of clinical applications. Nevertheless, it is imperative to conduct comprehensive scientific research and rigorous clinical trials to effectively apply these discoveries to real-world medical interventions, while prioritizing patient safety and therapeutic effectiveness.