Cardiac sarcoidosis (CS) is a potentially life-threatening condition that can cause sudden, fatal conduction abnormalities, arrhythmias, and heart failure. The diagnosis of CS is challenging due to nonspecific symptoms and an unclear diagnostic criterion. Although biopsy is the gold standard method, the sensitivity of biopsy is low. About a portion of CS cases are detected through imaging. A unique aspect of our case is that our definitive diagnosis was made based on clinical and imaging criteria alone despite a negative biopsy. Our diagnosis was confirmed further on follow-up with improvement in cardiac function on imaging after a treatment course with corticosteroids. This case highlights the need to have a broad differential and more awareness of this rare etiology and the value of clinical criteria to make a definitive diagnosis.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10858628PMC
http://dx.doi.org/10.7759/cureus.52088DOI Listing

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Article Synopsis
  • Sarcoidosis is a rare chronic disease with an unclear cause, making cardiac sarcoidosis (CS) diagnosis particularly challenging.
  • Current guidelines for diagnosing CS lack clinical validation, and while endomyocardial biopsy is specific, it is not very sensitive and has significant risks.
  • A case study of a 63-year-old man diagnosed with CS through endobronchial ultrasound transbronchial needle aspiration (EBUS TBNA) of normal lymph nodes suggests that EBUS TBNA could be a viable option for diagnosing CS in cases without clear pulmonary sarcoidosis evidence.
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Background: Granulomatosis with polyangiitis (GPA) is an autoimmune multisystem disorder characterized by small vessel vasculitis with granulomatous inflammation. In this report, we describe a unique case of GPA who presented with complete heart block (CHB) and developed complications due to intracranial large vessel involvement.

Case Summary: A 47-year-old gentleman presented with CHB with a background history of arthralgia and blood-tinged nasal discharge.

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Aims: The prognostic role of high-sensitivity cardiac troponin T (hs-cTnT) as a biomarker in patients with cardiac sarcoidosis (CS) has yet to be fully determined, especially when compared with B-type natriuretic peptide (BNP).

Methods And Results: In this post-hoc analysis of the ILLUMINATE-CS (ILLUstration of the Management and prognosIs of JapaNese pATiEnts with Cardiac Sarcoidosis), which is a multicentre retrospective observational study, we analysed 103 patients (62.2 ± 10.

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