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Predicting immune risk in treatment-naïve HIV patients using a machine learning algorithm: a decision tree algorithm based on micronutrients and inversion of the CD4/CD8 ratio.
Front Nutr
October 2024
Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Bhubaneswar, India.
Introduction: Micronutrients have significant functional implications for the human immune response, and the quality of food is a major factor affecting the severity and mortality caused by HIV in individuals undergoing antiretroviral therapy. A decrease in CD4 lymphocyte count and an increase in CD8 lymphocyte count are the hallmarks of HIV infection, which causes the CD4/CD8 ratio to invert from a normal value of >1.6 to <1.
View Article and Find Full Text PDFNew mutations and new phenotypes: a case of Major Histocompatibility Complex Class II Deficiency.
Immunol Res
December 2024
Department of Pediatric Critical Medicine, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, 1617 Riyue Avenue, Qingyang District, Chengdu, 611731, China.
Major Histocompatibility Complex Class II Deficiency is a rare primary immunodeficiency disease with autosomal recessive inheritance. It is characterized by the absence of Major Histocompatibility Complex Class II molecules on the surface of immune cells. In this article, we will present a four-month-old baby girl who presented with recurrent fever and progressive exacerbation of respiratory symptoms since a month ago.
View Article and Find Full Text PDFOne Virus, Two Diseases: Evaluation of Clinical and Immunological Differences in Covid-19 and Multisystem Inflammatory Syndrome Cases.
Sisli Etfal Hastan Tip Bul
April 2024
Department of Pediatric Allergy and Immunology, Ondokuz Mayis University Faculty of Medicine, Samsun, Türkiye.
Objectives: This study aims to uncover early detection markers through the immunological analysis of children diagnosed with multisystem inflammatory syndrome (MIS-C) and coronavirus disease-2019 (COVID-19).
Methods: We retrospectively analyzed immunological data from thirty-three MIS-C patients and an equivalent number of patients under the age of 18 with a positive polymerase chain reaction (PCR) test for COVID-19. These individuals were admitted to Ondokuz Mayis University between November 2020 and February 2021.
[Immunophenotyping by spectral cytometry reveals a profile of lymphopenia associated with deregulation with an increase in effector memory lymphocytes in a patient with a mutation in the ITPR3 gene].
Rev Alerg Mex
February 2024
Instituto de Investigaciones Inmunológicas, Universidad de Cartagena, Cartagena, Colombia.
Background: Variants in intracellular calcium transport genes have been associated with syndromic immunodeficiencies with a SCID phenotype.
Case Report: Seven-year-old girl of non-consanguineous parents, in Cartagena-Colombia. At two months of age, he presented hematochezia and was diagnosed with alimentary proctolitis without improvement with restriction to milk, wheat and eggs, and malnutrition developed.
Combining CD4 count, CD8 count and CD4/CD8 ratio to predict risk of mortality among HIV-positive adults after therapy: a group-based multi-trajectory analysis.
Front Immunol
December 2023
Institute of Preventive Medicine, Shandong University, Jinan, Shandong, China.
Introduction: Previous studies have indicated different immunological recovery trajectories based on CD4 count or CD4/CD8 ratio. However, these immune indicators are interconnected, and relying solely on one indicator may lead to inaccurate estimates. Therefore, it is essential to develop a comprehensive trajectory model that integrates CD4 count, CD8 count and CD4/CD8 ratio.
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