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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10851770 | PMC |
| http://dx.doi.org/10.37825/2239-9747.1045 | DOI Listing |
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Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut.
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Oxidative stress plays a crucial role in organ aging and related diseases, yet the endogenous regulators involved remain largely unknown. This work highlights the importance of metabolic homeostasis in protecting against oxidative stress in the large intestine. By developing a low-input and user-friendly pipeline for the simultaneous profiling of five distinct cysteine (Cys) states, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S-nitrosylation (SNO), and S-glutathionylation (SSG), we shed light on Cys redox modification stoichiometries and signaling with regional resolution in the aging gut of monkeys.
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